John G Houston
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Explore the profile of John G Houston including associated specialties, affiliations and a list of published articles.
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12
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206
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Recent Articles
1.
Snyder L, Neklesa T, Willard R, Gordon D, Pizzano J, Vitale N, et al.
Mol Cancer Ther
. 2024 Dec;
PMID: 39670468
Androgen receptor (AR) signaling is the principal driver of prostate cancer, and drugs that target this pathway (e.g., abiraterone and enzalutamide) are standard treatments for metastatic hormone-sensitive prostate cancer and...
2.
Singh A, Horsfield M, Bekele S, Greenwood J, Dawson D, Berry C, et al.
Eur Radiol
. 2018 Nov;
29(5):2340-2349.
PMID: 30488106
Objectives: To compare aortic size and stiffness parameters on MRI between bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV) patients with aortic stenosis (AS). Methods: MRI was performed in...
3.
MacDonald C, Gandy S, Avison E, Matthew S, Ross R, Houston J
MAGMA
. 2018 Aug;
31(6):735-745.
PMID: 30132298
Objective: To compare non-contrast enhanced MRI with ultrasound (US) for measurement of arm blood vessel geometries and flow velocities in volunteers and patients with end-stage renal disease. Materials And Methods:...
4.
Gillman K, Starrett Jr J, Parker M, Xie K, Bronson J, Marcin L, et al.
ACS Med Chem Lett
. 2014 Jun;
1(3):120-4.
PMID: 24900185
During the course of our research efforts to develop a potent and selective γ-secretase inhibitor for the treatment of Alzheimer's disease, we investigated a series of carboxamide-substituted sulfonamides. Optimization based...
5.
Jennings C, Houston J, Severn A, Bell S, Mackenzie I, MacDonald T
Curr Atheroscler Rep
. 2014 Apr;
16(6):416.
PMID: 24743868
Renal artery stensosis (RAS) continues to be a problem for clinicians, with no clear consensus on how to investigate and assess the clinical significance of stenotic lesions and manage the...
6.
Szwejkowski B, Gandy S, Rekhraj S, Houston J, Lang C, Morris A, et al.
J Am Coll Cardiol
. 2013 Sep;
62(24):2284-93.
PMID: 23994420
Objectives: This study sought to ascertain whether high-dose allopurinol causes regression of left ventricular mass (LVM) in patients with type 2 diabetes mellitus (T2DM). Background: Left ventricular hypertrophy (LVH) is...
7.
Luo G, Chen L, Conway C, Denton R, Keavy D, Signor L, et al.
J Med Chem
. 2012 Nov;
55(23):10644-51.
PMID: 23153230
Calcitonin gene-related peptide (CGRP) receptor antagonists have demonstrated clinical efficacy in the treatment of acute migraine. Herein, we describe the design, synthesis, and preclinical characterization of a highly potent, oral...
8.
Zhang L, Cvijic M, Lippy J, Myslik J, Brenner S, Binnie A, et al.
Drug Discov Today
. 2012 Mar;
17(13-14):733-40.
PMID: 22425710
In this paper, we review the key solutions that enabled evolution of the lead optimization screening support process at Bristol-Myers Squibb (BMS) between 2004 and 2009. During this time, technology...
9.
Matson S, Chatterjee M, Stock D, Leet J, Dumas E, Ferrante C, et al.
J Biomol Screen
. 2009 Jun;
14(5):476-84.
PMID: 19483144
Preserving the integrity of the compound collection and providing high-quality materials for drug discovery in an efficient and cost-effective manner are 2 major challenges faced by compound management (CM) at...
10.
Houston J, Banks M, Binnie A, Brenner S, OConnell J, Petrillo E
Drug Discov Today
. 2008 Jan;
13(1-2):44-51.
PMID: 18190863
We review strategic approaches taken over an eight-year period at BMS to implement new high-throughput approaches to lead discovery. Investments in compound management infrastructure and chemistry library production capability allowed...