John E Hughes
Overview
Explore the profile of John E Hughes including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
32
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Recent Articles
1.
Chen C, Pham Nguyen T, Hughes J, Hennessy S, Leonard C, Miano T, et al.
Pharmacoepidemiol Drug Saf
. 2025 Jan;
34(1):e70088.
PMID: 39805810
Drug-drug interactions (DDIs) represent a significant concern for clinical care and public health, but the health consequences of many DDIs remain largely underexplored. This knowledge gap underscores the critical need...
2.
Hughes J, Menditto E, Mucherino S, Orlando V, Moreno-Juste A, Gimeno-Miguel A, et al.
Pharmacoepidemiol Drug Saf
. 2025 Jan;
34(1):e70092.
PMID: 39777812
Background: Drug-drug interactions (DDIs), highly prevalent amongst the elderly, can lead to avoidable medication-related harm. Cardiovascular and central nervous system (CNS) drugs are commonly implicated. To date, there is no...
3.
Hughes J, Bennett K, Cahir C
Clin Drug Investig
. 2024 Jun;
44(6):439-453.
PMID: 38878216
Background: Evidence on associations between drug-drug interactions (DDIs) and health outcomes in the older community-dwelling population is limited. Objective: We estimate potentially clinically important DDI prevalence and examine the association...
4.
Brannigan R, Hughes J, Moriarty F, Wallace E, Kirke C, Williams D, et al.
J Clin Med
. 2024 Jan;
13(2).
PMID: 38256457
Background: This study aimed to determine the prevalence of potentially inappropriate prescribing (PIP) and potential prescribing omissions (PPOs) and their association with ADR-related hospital admissions in patients aged ≥ 65...
5.
Hughes J, Moriarty F, Bennett K, Cahir C
Br J Clin Pharmacol
. 2023 Nov;
90(4):959-975.
PMID: 37984336
Aims: The aims of this study were to estimate potentially clinically important drug-drug interaction (DDI) prevalence, and the average causal effect of DDI exposure on adverse drug reaction (ADR)-related hospital...
6.
Hughes J, Waldron C, Bennett K, Cahir C
Drugs Aging
. 2023 Jan;
40(2):117-134.
PMID: 36692678
Background: Drug-drug interactions (DDIs) can lead to medication-related harm, and the older population is at greatest risk. We conducted a systematic review and meta-analysis to estimate DDI prevalence and identify...
7.
Hughes J, Buckley N, Looney Y, Kirwan G, Mullooly M, Bennett K
Pharmacoepidemiol Drug Saf
. 2022 Sep;
32(2):137-147.
PMID: 36073295
Purpose: In 2018, following an EU-wide safety review, a revised pregnancy prevention programme (PPP) was introduced for isotretinoin (Roaccutane®). This study aimed to examine awareness, knowledge, and experience implementing the...
8.
Hughes J, Buckley N, Looney Y, Curran S, Mullooly M, Bennett K
Pharmacoepidemiol Drug Saf
. 2022 Mar;
31(6):661-669.
PMID: 35285110
Purpose: This study aimed to examine trends in valproate use among women of childbearing potential (WCBP) aged 16-44 years in Ireland following two European-directed regulatory interventions in December 2014 and...
9.
Hughes J, Russo V, Walsh C, Menditto E, Bennett K, Cahir C
Drugs Aging
. 2021 Oct;
38(11):1025-1037.
PMID: 34632551
Background: Older patients are at increased risk of drug-drug interactions (DDIs) due to polypharmacy. Cardiovascular and central nervous system (CNS) drugs are commonly implicated in serious DDIs. Objectives: This study...
10.
Hughes J, Buckley N, Looney Y, Kirwan G, Curran S, Doherty C, et al.
Expert Opin Drug Saf
. 2021 Jun;
20(8):965-977.
PMID: 34080507
Objectives: To establish awareness, knowledge, use and experience in practice of a sodium valproate pregnancy prevention program (PPP) in Ireland ("prevent") among three healthcare professional (HCP) groups. Methods: A cross-sectional...