John E Chittum
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Explore the profile of John E Chittum including associated specialties, affiliations and a list of published articles.
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4
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29
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Recent Articles
1.
Chittum J, Thompson A, Desai U
Carbohydr Polym
. 2024 Apr;
335:122106.
PMID: 38616080
More than 3000 proteins are now known to bind to glycosaminoglycans (GAGs). Yet, GAG-protein systems are rather poorly understood in terms of selectivity of recognition, molecular mechanism of action, and...
2.
Sankaranarayanan N, Sistla S, Nagarajan B, Chittum J, Lau J, Desai U
Glycobiology
. 2023 May;
33(7):579-590.
PMID: 37171590
Despite decades of research, glycosaminoglycans (GAGs) have not been known to interact with sialyl transferases (STs). Using our in-house combinatorial virtual library screening (CVLS) technology, we studied seven human isoforms,...
3.
Boothello R, Sankaranarayanan N, Sistla J, Nagarajan B, Sharon C, Chittum J, et al.
Angew Chem Int Ed Engl
. 2022 Oct;
61(49):e202211320.
PMID: 36205924
The insulin-like growth factor-1 receptor (IGF-1R) is a receptor tyrosine kinase (RTK) that plays critical roles in cancer. Microarray, computational, thermodynamic, and cellular imaging studies reveal that activation of IGF-1R...
4.
Chittum J, Sankaranarayanan N, OHara C, Desai U
ACS Med Chem Lett
. 2021 Nov;
12(11):1710-1717.
PMID: 34786180
SARS-CoV-2 infects human cells through its surface spike glycoprotein (SgP), which relies on host cell surface heparan sulfate (HS) proteoglycans that facilitate interaction with the ACE2 receptor. Targeting this process...