John de Jersey
Overview
Explore the profile of John de Jersey including associated specialties, affiliations and a list of published articles.
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42
Citations
443
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Recent Articles
1.
Zhao K, Dimeski G, Masci P, Johnson L, Wang J, de Jersey J, et al.
Biomolecules
. 2024 Jun;
14(6).
PMID: 38927049
We recently reported the potential application of recombinant prothrombin activator ecarin (RAPClot™) in blood diagnostics. In a new study, we describe RAPClot™ as an additive to develop a novel blood...
2.
Zhao K, Masci P, Dimeski G, Johnson L, Grant M, de Jersey J, et al.
Biomolecules
. 2022 Nov;
12(11).
PMID: 36421717
We describe here the purification and cloning of a codon-optimized form of the snake prothrombin activator ecarin from the saw scaled viper () expressed in mammalian cells. Expression of recombinant...
3.
Johnson L, de Jersey J, Masci P, Zhao K, Bennett N, Dimeski G, et al.
Anal Biochem
. 2020 Aug;
608:113907.
PMID: 32814078
Snake venom prothrombin activators such as Ecarin are readily assayed by continuous spectrophotometric monitoring of p-nitroaniline production in a one step assay containing prothrombin and a p-nitroanilide peptide substrate for...
4.
Zhao K, Dimeski G, de Jersey J, Johnson L, Grant M, Masci P, et al.
Biochem Med (Zagreb)
. 2019 Oct;
29(3):030706.
PMID: 31624459
Introduction: Failure to obtain complete blood clotting in serum is a common laboratory problem. Our aim was to determine whether snake proth-rombin activators are effective in clotting blood and producing...
5.
Zhao K, Dimeski G, de Jersey J, Johnson L, Grant M, Masci P, et al.
Clin Chem Lab Med
. 2018 Sep;
57(4):483-497.
PMID: 30267622
Background Incomplete blood clotting or latent clotting in serum is a common laboratory problem, especially for patients on anticoagulant therapy or when serum tubes are centrifuged before clotting is completed....
6.
Du Q, Trabi M, Richards R, Mirtschin P, Madaras F, Nouwens A, et al.
Toxicon
. 2016 Jan;
111:37-49.
PMID: 26747471
Pseudechis australis is one of the most venomous and lethal snakes in Australia. Numerous phospholipase A2 (PLA2) isoforms constitute a major portion of its venom, some of which have previously...
7.
Keough D, Hockova D, Rejman D, Spacek P, Vrbkova S, Krecmerova M, et al.
J Med Chem
. 2013 Aug;
56(17):6967-84.
PMID: 23927482
Escherichia coli (Ec) cells possess two purine salvage enzymes: xanthine-guanine phosphoribosyltransferase (XGPRT) and hypoxanthine phosphoribosyltransferase (HPRT). EcXGPRT shares a common structural feature with other members of this family, a flexible...
8.
Keough D, Spacek P, Hockova D, Tichy T, Vrbkova S, Slavetinska L, et al.
J Med Chem
. 2013 Mar;
56(6):2513-26.
PMID: 23448281
Acyclic nucleoside phosphonates (ANPs) that contain a 6-oxopurine base are good inhibitors of the Plasmodium falciparum (Pf) and Plasmodium vivax (Pv) 6-oxopurine phosphoribosyltransferases (PRTs). Chemical modifications based on the crystal...
9.
Millers E, Johnson L, Birrell G, Masci P, Lavin M, de Jersey J, et al.
PLoS One
. 2013 Jan;
8(1):e54104.
PMID: 23335990
Textilinin-1 is a Kunitz-type serine protease inhibitor from Australian brown snake venom. Its ability to potently and specifically inhibit human plasmin (K(i) = 0.44 nM) makes it a potential therapeutic...
10.
Hockova D, Keough D, Janeba Z, Wang T, de Jersey J, Guddat L
J Med Chem
. 2012 Jun;
55(13):6209-23.
PMID: 22725979
Hypoxanthine-guanine-(xanthine) phosphoribosyltransferase (HG(X)PRT) is crucial for the survival of malarial parasites Plasmodium falciparum (Pf) and Plasmodium vivax (Pv). Acyclic nucleoside phosphonates (ANPs) are inhibitors of HG(X)PRT and arrest the growth...