John D Fissekis
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Explore the profile of John D Fissekis including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Conti P, Bading J, Mouton P, Links J, Alauddin M, Fissekis J, et al.
Nucl Med Biol
. 2007 Dec;
35(1):131-41.
PMID: 18158952
Introduction: Noncatabolized thymidine analogs are being developed for use in imaging DNA synthesis. We sought to relate a labeling index measured by immunohistochemical staining bromodeoxyuridine (BUdR) technique to the uptake...
2.
Alauddin M, Shahinian A, Park R, Tohme M, Fissekis J, Conti P
Nucl Med Biol
. 2007 Mar;
34(3):267-72.
PMID: 17383576
Introduction: Many fluorinated analogues of adenosine nucleoside have been synthesized and studied as potential antitumor and antiviral agents. Earlier, we reported radiosynthesis of 2'-deoxy-2'-[(18)F]fluoro-1-beta-D-arabinofuranosyl-adenine ([(18)F]-FAA) and 3'-deoxy-3'-[(18)F]fluoro-1-beta-d-xylofuranosyl-adenine ([(18)F]FXA). Now, we...
3.
Alauddin M, Shahinian A, Park R, Tohme M, Fissekis J, Conti P
Eur J Nucl Med Mol Imaging
. 2007 Jan;
34(6):822-9.
PMID: 17206416
Purpose: FIAU and FEAU were evaluated in vitro and in vivo as markers for HSV1-tk gene expression. Methods: In vitro and biodistribution studies were performed in wild type and transduced...
4.
Alauddin M, Shahinian A, Park R, Tohme M, Fissekis J, Conti P
J Nucl Med
. 2004 Dec;
45(12):2063-9.
PMID: 15585483
Unlabelled: 2'-deoxy-2'-(18)F-fluoro-5-fluoro-1-beta-D-arabinofuranosyluracil ((18)F-FFAU) has been synthesized and evaluated in HT-29 cells as a potential PET agent for herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene expression. Methods: 2-Deoxy-2-(18)F-fluoro-1,3,5-tri-O-benzoyl-alpha-D-arabinofuranose was...
5.
Bading J, Shahinian A, Vail A, Bathija P, Koszalka G, Koda R, et al.
Nucl Med Biol
. 2004 Apr;
31(4):407-18.
PMID: 15093810
The thymidine analog 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (FMAU) is incorporated into DNA and is resistant to catabolism. We performed pharmacokinetic measurements with [(14)C]FMAU and PET studies with [(11)C]FMAU using rats bearing several different...
6.
Alauddin M, Shahinian A, Park R, Tohme M, Fissekis J, Conti P
Nucl Med Biol
. 2004 Apr;
31(4):399-405.
PMID: 15093809
[(18)F]-FBAU and [(18)F]-FCAU have been synthesized and evaluated in vivo as markers for HSV1-tk gene expression. At 2 hours, uptake of [(18)F]-FBAU and [(18)F]-FCAU in HSV1-tk-positive tumors was 7.9-fold and...
7.
Bading J, Yoo P, Fissekis J, Alauddin M, DArgenio D, Conti P
Cancer Res
. 2003 Jul;
63(13):3667-74.
PMID: 12839957
Drug uptake and anabolism by tumors are prerequisites of response to 5-fluorouracil (5-FU). Positron emission tomography (PET) with 5-[(18)F]FU (PET/5-[(18)F]FU) is potentially useful for noninvasive measurement of these processes, but...