John D Brennan
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Explore the profile of John D Brennan including associated specialties, affiliations and a list of published articles.
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121
Citations
1200
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Recent Articles
1.
Nurmi C, Gu J, Mathai A, Brennan J, Li Y
Nucleic Acids Res
. 2024 Sep;
52(18):11177-11187.
PMID: 39248110
The 10-23 DNAzyme is one of the most active DNA-based enzymes, and in theory, can be designed to target any purine-pyrimidine junction within an RNA sequence for cleavage. However, purine-pyrimidine...
2.
Ali M, Nair P, Capretta A, Brennan J
Chembiochem
. 2024 Apr;
25(11):e202400085.
PMID: 38574237
Over the last three decades, significant advancements have been made in the development of biosensors and bioassays that use RNA-cleaving DNAzymes (RCDs) as molecular recognition elements. While early examples of...
3.
Ali M, Mukherjee M, Radford K, Patel Z, Capretta A, Nair P, et al.
Angew Chem Int Ed Engl
. 2023 Jul;
62(38):e202307451.
PMID: 37477970
The first protein-binding allosteric RNA-cleaving DNAzyme (RCD) obtained by direct in vitro selection against eosinophil peroxidase (EPX), a validated marker for airway eosinophilia, is described. The RCD has nanomolar affinity...
4.
Wu Y, Chang D, Chang Y, Zhang Q, Liu Y, Brennan J, et al.
Small
. 2023 Jun;
19(41):e2303007.
PMID: 37294164
clustered regularly interspaced short palindromic repeats (CRISPR)-Cas systems are increasingly used in biosensor development. However, directly translating recognition events for non-nucleic acid targets by CRISPR into effective measurable signals represents...
5.
Gu J, Mathai A, Nurmi C, White D, Panesar G, Yamamura D, et al.
Chemistry
. 2023 Feb;
29(27):e202300075.
PMID: 36790320
A new method for the detection of genomic RNA combines RNA cleavage by the 10-23 DNAzyme and use of the cleavage fragments as primers to initiate rolling circle amplification (RCA)....
6.
Ali M, Wolfe M, Mukherjee M, Radford K, Patel Z, White D, et al.
Sci Rep
. 2022 Dec;
12(1):22476.
PMID: 36577785
Eosinophils are granulocytes that play a significant role in the pathogenesis of asthma and other airway diseases. Directing patient treatment based on the level of eosinophilia has been shown to...
7.
Li J, Zhang Z, Gu J, Amini R, Mansfield A, Xia J, et al.
J Am Chem Soc
. 2022 Dec;
144(51):23465-23473.
PMID: 36520671
Our previously discovered monomeric aptamer for SARS-CoV-2 (MSA52) possesses a universal affinity for COVID-19 spike protein variants but is ultimately limited by its ability to bind only one subunit of...
8.
Bialy R, Mainguy A, Li Y, Brennan J
Chem Soc Rev
. 2022 Oct;
51(21):9009-9067.
PMID: 36259976
Functional nucleic acids (FNAs), including DNA aptamers and DNAzymes, are finding increasing use as molecular recognition elements for point-of-care (POC) assays and sensors. An ongoing challenge in the development of...
9.
Amini R, Zhang Z, Li J, Gu J, Brennan J, Li Y
Anal Sens
. 2022 Aug;
2(5):e202200035.
PMID: 35936648
nucleic acid aptamers armed and ready for our battle against the monstrous SARS-CoV-2 virus. Often thought of as "chemical antibodies", these molecular recognition elements are equipped with several unique benefits...
10.
Xue W, Zhang Q, Chang Y, Brennan J, Li Y, Liu M
Chem Sci
. 2022 Jun;
13(22):6496-6501.
PMID: 35756503
We report on a paper-based sensor capable of performing template-independent DNA synthesis by terminal deoxynucleotidyl transferase (TdT). Importantly, we observed that TdT efficiently incorporates fluorescently labeled dUTP on to 3'-OH...