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John Cafferkey

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Articles 14
Citations 67
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Recent Articles
1.
Cafferkey J, Shankar-Hari M
Semin Respir Crit Care Med . 2024 Jul; 45(4):516-522. PMID: 38977014
Sepsis pathobiology is complex. Heterogeneity refers to the clinical and biological variation within sepsis cohorts. Sepsis subtypes refer to subpopulations within sepsis cohorts derived based on these observable variations and...
2.
Gray A, Oatey K, Grahamslaw J, Irvine S, Cafferkey J, Kennel T, et al.
Crit Care Med . 2024 Jun; 52(10):1520-1532. PMID: 38912884
Objectives: International guidelines recommend IV crystalloid as the primary fluid for sepsis resuscitation, with 5% human albumin solution (HAS) as the second line. However, it is unclear which fluid has...
3.
Cafferkey J, Ferguson A, Grahamslaw J, Oatey K, Norrie J, Lone N, et al.
J Intensive Care Soc . 2023 Mar; 24(1):78-84. PMID: 36860553
Background: Patients presenting with suspected sepsis to secondary care often require fluid resuscitation to correct hypovolaemia and/or septic shock. Existing evidence signals, but does not demonstrate, a benefit for regimes...
4.
Wong C, Gregory J, Liao J, Egan K, Vesterinen H, Ahmad Khan A, et al.
BMJ Open . 2023 Feb; 13(2):e064169. PMID: 36725099
Objectives: Motor neuron disease (MND) is an incurable progressive neurodegenerative disease with limited treatment options. There is a pressing need for innovation in identifying therapies to take to clinical trial....
5.
Cafferkey J, Padayachee Y, Kostich S, Kumar K, Jewell P, Patel M, et al.
ERJ Open Res . 2022 Dec; 8(4). PMID: 36451845
Background: Systemic biologic agents can increase the risk of re-activation of latent tuberculosis (TB). Prior to initiation, screening for latent TB using an interferon-γ release assay (IGRA) is recommended. There...
6.
Cafferkey J, Serebriakoff P, de Wit K, Horner D, Reed M
Emerg Med J . 2022 Jul; 39(12):945-951. PMID: 35868848
This first of two practice reviews addresses pulmonary embolism (PE) diagnosis considering important aspects of PE clinical presentation and comparing evidence-based PE testing strategies. A companion paper addresses the management...
7.
Forsythe R, Eng C, Roy C, Cafferkey J, Clinch D, Ventham N, et al.
Br J Surg . 2022 Jun; 109(8):711-716. PMID: 35716129
Background: Since 1999, the Scottish National Service for Thoracoabdominal Aneurysms has offered repair of thoracoabdominal aneurysms (TAAAs) to a population of 5.5 million people. The open operation most commonly performed...
8.
Padayachee Y, Flicker S, Linton S, Cafferkey J, Kon O, Johnston S, et al.
Front Allergy . 2022 Apr; 2:668781. PMID: 35387044
The nose provides a route of access to the body for inhalants and fluids. Unsurprisingly it has a strong immune defense system, with involvement of innate (e.g., epithelial barrier, muco-...
9.
Serebriakoff P, Cafferkey J, de Wit K, Horner D, Reed M
Emerg Med J . 2022 Apr; 40(1):69-75. PMID: 35383107
Pulmonary embolism (PE) can present with a range of severity. Prognostic risk stratification is important for efficacious and safe management. This second of two review articles discusses the management of...
10.
Coultas J, Cafferkey J, Mallia P, Johnston S
J Exp Pharmacol . 2021 Jul; 13:645-659. PMID: 34276229
Rhinovirus infection is common and usually causes mild, self-limiting upper respiratory tract symptoms. Rhinoviruses can cause exacerbation of chronic respiratory diseases, such as asthma or chronic obstructive pulmonary disease, leading...