John C Chappell
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Explore the profile of John C Chappell including associated specialties, affiliations and a list of published articles.
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34
Citations
791
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Recent Articles
1.
Abdelazim H, Barnes A, Stupin J, Hasson R, Munoz-Ballester C, Young K, et al.
bioRxiv
. 2024 Sep;
PMID: 39345630
Highlights: We optimized a protocol for the enrichment of murine capillaries using density gradient centrifugation and follow-on filtration.We offer an approach to analyzing post-collection cerebrovascular fragments and cells with respect...
2.
Payne L, Abdelazim H, Hoque M, Barnes A, Mironovova Z, Willi C, et al.
Biomolecules
. 2023 May;
13(4).
PMID: 37189457
The platelet-derived growth factor-BB (PDGF-BB) pathway provides critical regulation of cerebrovascular pericytes, orchestrating their investment and retention within the brain microcirculation. Dysregulated PDGF Receptor-beta (PDGFRβ) signaling can lead to pericyte...
3.
Payne L, Abdelazim H, Hoque M, Barnes A, Mironovova Z, Willi C, et al.
bioRxiv
. 2023 Feb;
PMID: 36778261
The platelet-derived growth factor-BB (PDGF-BB) pathway provides critical regulation of cerebrovascular pericytes, orchestrating their investment and retention within the brain microcirculation. Dysregulated PDGF Receptor-beta (PDGFRβ) signaling can lead to pericyte...
4.
Abdelazim H, Payne L, Nolan K, Paralkar K, Bradley V, Kanodia R, et al.
Front Physiol
. 2023 Jan;
13:1016382.
PMID: 36589416
Confident identification of pericytes (PCs) remains an obstacle in the field, as a single molecular marker for these unique perivascular cells remains elusive. Adding to this challenge is the recent...
5.
Willi C, Abdelazim H, Chappell J
Front Bioeng Biotechnol
. 2022 Dec;
10:1008481.
PMID: 36568288
Numerous disease conditions involve the sudden or progressive loss of blood flow. Perfusion restoration is vital for returning affected organs to full health. While a range of clinical interventions can...
6.
Sedovy M, Leng X, Leaf M, Iqbal F, Payne L, Chappell J, et al.
J Vasc Res
. 2022 Dec;
60(2):101-113.
PMID: 36513042
Connexin 43 (Cx43) is essential to the function of the vasculature. Cx43 proteins form gap junctions that allow for the exchange of ions and molecules between vascular cells to facilitate...
7.
Payne L, Tewari B, Dunkenberger L, Bond S, Savelli A, Darden J, et al.
Arterioscler Thromb Vasc Biol
. 2022 Feb;
42(4):e96-e114.
PMID: 35139658
Background: Vascular pericytes stabilize blood vessels and contribute to their maturation, while playing other key roles in microvascular function. Nevertheless, relatively little is known about involvement of their precursors in...
8.
Payne L, Hoque M, Houk C, Darden J, Chappell J
Curr Tissue Microenviron Rep
. 2021 Mar;
1(3):143-154.
PMID: 33748774
Purpose Of Review: Pericytes are essential components of capillaries in many tissues and organs, contributing to vessel stability and integrity, with additional contributions to microvascular function still being discovered. We...
9.
Pericyte migration and proliferation are tightly synchronized to endothelial cell sprouting dynamics
Payne L, Darden J, Suarez-Martinez A, Zhao H, Hendricks A, Hartland C, et al.
Integr Biol (Camb)
. 2021 Jan;
13(2):31-43.
PMID: 33515222
Pericytes are critical for microvascular stability and maintenance, among other important physiological functions, yet their involvement in vessel formation processes remains poorly understood. To gain insight into pericyte behaviors during...
10.
Hoque M, Abdelazim H, Jenkins-Houk C, Wright D, Patel B, Chappell J
Microcirculation
. 2020 Nov;
28(3):e12671.
PMID: 33171539
Microvascular networks are vital components of the cardiovascular system, performing many key roles in maintaining the health and homeostasis of the tissues and organs in which they develop. As discussed...