John Bringas
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Explore the profile of John Bringas including associated specialties, affiliations and a list of published articles.
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44
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1474
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Recent Articles
1.
Ford M, George B, Van Laar V, Holleran K, Naidoo J, Hadaczek P, et al.
Nat Med
. 2023 Aug;
29(8):2030-2040.
PMID: 37580533
Alcohol use disorder (AUD) exacts enormous personal, social and economic costs globally. Return to alcohol use in treatment-seeking patients with AUD is common, engendered by a cycle of repeated abstinence-relapse...
2.
Luz M, Allen P, Bringas J, Boiko C, Stockinger D, Nikula K, et al.
Arch Toxicol
. 2018 May;
92(7):2353-2367.
PMID: 29785638
Glial cell line-derived neurotrophic factor (GDNF) has demonstrated neurorestorative and neuroprotective effects in rodent and nonhuman primate models of Parkinson's disease. However, continuous intraputamenal infusion of GDNF (100 µg/day) resulted...
3.
Yazdan-Shahmorad A, Tian N, Kharazia V, Samaranch L, Kells A, Bringas J, et al.
J Neurosci Methods
. 2017 Oct;
293:347-358.
PMID: 29042259
Background: In non-human primate (NHP) optogenetics, infecting large cortical areas with viral vectors is often a difficult and time-consuming task. Previous work has shown that parenchymal delivery of adeno-associated virus...
4.
Hadaczek P, Stanek L, Ciesielska A, Sudhakar V, Samaranch L, Pivirotto P, et al.
Mol Ther Methods Clin Dev
. 2016 Jul;
3:16037.
PMID: 27408903
Huntington's disease (HD) is caused by a toxic gain-of-function associated with the expression of the mutant huntingtin (htt) protein. Therefore, the use of RNA interference to inhibit Htt expression could...
5.
Meneghini V, Lattanzi A, Tiradani L, Bravo G, Morena F, Sanvito F, et al.
EMBO Mol Med
. 2016 Mar;
8(5):489-510.
PMID: 27025653
Metachromatic leukodystrophy (MLD) and globoid cell leukodystrophy (GLD or Krabbe disease) are severe neurodegenerative lysosomal storage diseases (LSD) caused by arylsulfatase A (ARSA) and galactosylceramidase (GALC) deficiency, respectively. Our previous...
6.
Bankiewicz K, Sudhakar V, Samaranch L, San Sebastian W, Bringas J, Forsayeth J
J Control Release
. 2016 Mar;
240:434-442.
PMID: 26924352
Gene transfer technology offers great promise as a potential therapeutic approach to the brain but has to be viewed as a very complex technology. Success of ongoing clinical gene therapy...
7.
Samaranch L, Bringas J, Pivirotto P, San Sebastian W, Forsayeth J, Bankiewicz K
Hum Gene Ther Methods
. 2016 Jan;
27(1):13-6.
PMID: 26757202
Accessing cerebrospinal fluid (CSF) from the craniocervical junction through the posterior atlanto-occipital membrane via cerebellomedullary injection (also known as cisternal puncture or cisterna magna injection) has become a standard procedure...
8.
Salegio E, Bringas J, Bankiewicz K
Methods Mol Biol
. 2015 Nov;
1382:217-30.
PMID: 26611589
Gene therapy has emerged as a potential avenue of treatment for many neurological disorders. Technological advances in imaging techniques allow for the monitoring of real-time infusions into the brain of...
9.
SAFETY AND TOLERABILITY OF MRI-GUIDED INFUSION OF AAV2-hAADC INTO THE MID-BRAIN OF NON-HUMAN PRIMATE
San Sebastian W, Kells A, Bringas J, Samaranch L, Hadaczek P, Ciesielska A, et al.
Mol Ther Methods Clin Dev
. 2014 Dec;
3.
PMID: 25541617
Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare, autosomal-recessive neurological disorder caused by mutations in the gene that leads to an inability to synthesize catecholamines and serotonin. As a...
10.
Salegio E, Streeter H, Dube N, Hadaczek P, Samaranch L, Kells A, et al.
Front Neuroanat
. 2014 Mar;
8:9.
PMID: 24672434
When nanoparticles/proteins are infused into the brain, they are often transported to distal sites in a manner that is dependent both on the characteristics of the infusate and the region...