John Brain
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Explore the profile of John Brain including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
413
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Recent Articles
1.
Gawish R, Maier B, Obermayer G, Watzenboeck M, Gorki A, Quattrone F, et al.
Elife
. 2022 Sep;
11.
PMID: 36178806
Sepsis is a life-threatening condition characterized by uncontrolled systemic inflammation and coagulation, leading to multiorgan failure. Therapeutic options to prevent sepsis-associated immunopathology remain scarce. Here, we established a mouse model...
2.
Jones D, Wetten A, Barron-Millar B, Ogle L, Mells G, Flack S, et al.
EBioMedicine
. 2022 May;
80:104068.
PMID: 35609437
Background: Uncertainty exists about how best to identify primary biliary cholangitis (PBC) patients who would benefit from second-line therapy. Existing, purely clinical, ursodeoxycholic acid (UDCA) response criteria accept degrees of...
3.
Barron-Millar B, Ogle L, Mells G, Flack S, Badrock J, Sandford R, et al.
Hepatology
. 2021 Jun;
74(6):3269-3283.
PMID: 34129689
Background And Aims: Stratified therapy has entered clinical practice in primary biliary cholangitis (PBC), with routine use of second-line therapy in nonresponders to first-line therapy with ursodeoxycholic acid (UDCA). The...
4.
Shalapour S, Lin X, Bastian I, Brain J, Burt A, Aksenov A, et al.
Nature
. 2018 Jul;
561(7721):E1.
PMID: 29973714
In this Article, the sentence: "After 7 months of HFD, MUP-uPA mice developed HCC, which contained numerous (usually 50-100 per tumour) non-recurrent coding mutations in pathways that are mutated in...
5.
Shalapour S, Lin X, Bastian I, Brain J, Burt A, Aksenov A, et al.
Nature
. 2017 Nov;
552(7685):430.
PMID: 29168501
This corrects the article DOI: 10.1038/nature24302.
6.
Shalapour S, Lin X, Bastian I, Brain J, Burt A, Aksenov A, et al.
Nature
. 2017 Nov;
551(7680):340-345.
PMID: 29144460
The role of adaptive immunity in early cancer development is controversial. Here we show that chronic inflammation and fibrosis in humans and mice with non-alcoholic fatty liver disease is accompanied...
7.
Asghar K, Brain J, Palmer J, Douglass S, Naemi F, OBoyle G, et al.
Oncol Lett
. 2017 Nov;
14(5):5497-5504.
PMID: 29113177
Indoleamine 2,3-dioxygenase (IDO)-induced immunosuppression can be clinically beneficial for autoimmune diseases. Primary biliary cirrhosis (PBC) is characterized by autoimmune lesions of intrahepatic bile duct epithelial cells that may lead to...
8.
Hardie C, Green K, Jopson L, Millar B, Innes B, Pagan S, et al.
EBioMedicine
. 2016 Dec;
14:65-73.
PMID: 27913155
High-risk primary biliary cholangitis (PBC), defined by inadequate response at one year to Ursodeoxycholic acid (UDCA), is associated with disease progression and liver transplantation. Stratifying high-risk patients early would facilitate...
9.
Moles A, Murphy L, Wilson C, Bagchi Chakraborty J, Fox C, Park E, et al.
J Hepatol
. 2013 Dec;
60(4):782-91.
PMID: 24333183
Background & Aims: Neutrophils are important immune effectors required for sterile and non-sterile inflammatory responses. However, neutrophils are associated with pathology in drug-induced liver injury, acute alcoholic liver disease, and...