John A Hassell
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Explore the profile of John A Hassell including associated specialties, affiliations and a list of published articles.
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48
Citations
1422
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Recent Articles
1.
Gwynne W, Shakeel M, Girgis-Gabardo A, Hassell J
Molecules
. 2021 Jun;
26(11).
PMID: 34073226
Breast tumors were the first tumors of epithelial origin shown to follow the cancer stem cell model. The model proposes that cancer stem cells are uniquely endowed with tumorigenic capacity...
2.
Gwynne W, Shakeel M, Girgis-Gabardo A, Kim K, Ford E, Dvorkin-Gheva A, et al.
BMC Cancer
. 2020 Aug;
20(1):724.
PMID: 32758183
Background: Breast tumor initiating cells (BTIC) are stem-like cells that initiate and sustain tumor growth, and drive disease recurrence. Identifying therapies targeting BTIC has been hindered due primarily to their...
3.
Gwynne W, Shakeel M, Wu J, Hallett R, Girgis-Gabardo A, Dvorkin-Gheva A, et al.
Cell Mol Biol Lett
. 2019 Nov;
24:59.
PMID: 31754354
Background: Breast tumor growth and recurrence are driven by an infrequent population of breast tumor-initiating cells (BTIC). We and others have reported that the frequency of BTIC is orders of...
4.
Elliott M, Jerzak K, Cockburn J, Safikhani Z, Gwynne W, Hassell J, et al.
Sci Rep
. 2018 Nov;
8(1):16562.
PMID: 30410118
Previous research has suggested that thyroid hormone receptor alpha 1 (THRα1), a hormone responsive splice variant, may play a role in breast cancer progression. Whether THRα1 can be exploited for...
5.
Vanderstocken G, Dvorkin-Gheva A, Shen P, Brandsma C, Obeidat M, Bosse Y, et al.
Am J Respir Cell Mol Biol
. 2017 Dec;
58(6):727-735.
PMID: 29256623
Cigarette smoking is the main risk factor for chronic obstructive pulmonary disease, and to date, existing pharmacologic interventions have been ineffective at controlling inflammatory processes associated with the disease. To...
6.
Singh M, Venugopal C, Tokar T, Brown K, McFarlane N, Bakhshinyan D, et al.
Acta Neuropathol
. 2017 Aug;
134(6):923-940.
PMID: 28766011
Brain metastases (BM) are the most common brain tumor in adults and are a leading cause of cancer mortality. Metastatic lesions contain subclones derived from their primary lesion, yet their...
7.
Gwynne W, Hallett R, Girgis-Gabardo A, Bojovic B, Dvorkin-Gheva A, Aarts C, et al.
Oncotarget
. 2017 Apr;
8(19):32101-32116.
PMID: 28404880
Breast tumors comprise an infrequent tumor cell population, termed breast tumor initiating cells (BTIC), which sustain tumor growth, seed metastases and resist cytotoxic therapies. Hence therapies are needed to target...
8.
Bassey-Archibong B, Rayner L, Hercules S, Aarts C, Dvorkin-Gheva A, Bramson J, et al.
Cell Death Dis
. 2017 Mar;
8(3):e2689.
PMID: 28333150
Triple negative breast cancers (TNBC) are highly aggressive and lack specific targeted therapies. Recent studies have reported high expression of the transcription factor Kaiso in triple negative tumors, and this...
9.
Dvorkin-Gheva A, Vanderstocken G, Yildirim A, Brandsma C, Obeidat M, Bosse Y, et al.
ERJ Open Res
. 2016 Dec;
2(4).
PMID: 27995131
Exposure of small animals to cigarette smoke is widely used as a model to study the pathogenesis of chronic obstructive pulmonary disease. However, protocols and exposure systems utilised vary substantially...
10.
Cockburn J, Hallett R, Gillgrass A, Dias K, Whelan T, Levine M, et al.
BMC Cancer
. 2016 Jul;
16:555.
PMID: 27469239
Background: Lymph node (LN) status is the most important prognostic variable used to guide ER positive (+) breast cancer treatment. While a positive nodal status is traditionally associated with a...