Johannes M van Noort
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Explore the profile of Johannes M van Noort including associated specialties, affiliations and a list of published articles.
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44
Citations
2140
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Recent Articles
1.
van Noort J, Baker D, Kipp M, Amor S
Clin Exp Immunol
. 2023 Jul;
214(1):1-17.
PMID: 37410892
Multiple sclerosis (MS) is characterized by the chronic inflammatory destruction of myelinated axons in the central nervous system. Several ideas have been put forward to clarify the roles of the...
2.
Hampton D, Amor S, Story D, Torvell M, Bsibsi M, van Noort J, et al.
Front Neurosci
. 2020 Jun;
14:574.
PMID: 32595446
Progressive neuronal death during tauopathies is associated with aggregation of modified, truncated or mutant forms of tau protein. Such aggregates are neurotoxic, promote spreading of tau aggregation, and trigger release...
3.
Erni S, Fernandes G, Buri M, Perny M, Rutten R, van Noort J, et al.
Front Neurol
. 2019 Jun;
10:570.
PMID: 31244750
Sensorineural hearing loss is the most common long-term deficit after pneumococcal meningitis (PM), occurring in up to 30% of surviving patients. The infection and the following overshooting inflammatory host response...
4.
van der Putten C, Veth J, Sukurova L, Zuiderwijk-Sick E, Simonetti E, Koenen H, et al.
J Immunol
. 2019 Feb;
202(8):2421-2430.
PMID: 30804043
TLR-induced signaling potently activates cells of the innate immune system and is subject to regulation at different levels. Inflammatory conditions are associated with increased levels of extracellular adenosine, which can...
5.
Holtman I, Bsibsi M, Gerritsen W, Boddeke H, Eggen B, van der Valk P, et al.
Glia
. 2017 Jan;
65(3):460-473.
PMID: 28063173
The glial stress protein alpha B-crystallin (HSPB5) is an endogenous agonist for Toll-like receptor 2 in CD14 cells. Following systemic administration, HSPB5 acts as a potent inhibitor of neuroinflammation in...
6.
Heat Shock Proteins: Old and Novel Roles in Neurodegenerative Diseases in the Central Nervous System
van Noort J, Bugiani M, Amor S
CNS Neurol Disord Drug Targets
. 2016 Nov;
16(3):244-256.
PMID: 27804858
Heat shock proteins (HSPs) are families of molecular chaperones that play important homeostatic functions in the central nervous system (CNS) by preventing protein misfolding, promoting degradation of improperly folded proteins,...
7.
Peferoen L, Breur M, van de Berg S, Peferoen-Baert R, Boddeke E, van der Valk P, et al.
Immunology
. 2016 Jul;
149(2):146-56.
PMID: 27388634
Current therapies for multiple sclerosis (MS) reduce the frequency of relapses by modulating adaptive immune responses but fail to limit the irreversible neurodegeneration driving progressive disability. Experimental autoimmune encephalomyelitis (EAE)...
8.
Puentes F, Malaspina A, van Noort J, Amor S
Brain Pathol
. 2016 Jan;
26(2):248-57.
PMID: 26780491
Neurological dysfunction and motor neuron degeneration in amyotrophic lateral sclerosis (ALS) is strongly associated with neuroinflammation reflected by activated microglia and astrocytes in the CNS. In ALS endogenous triggers in...
9.
Peferoen L, Gerritsen W, Breur M, Ummenthum K, Peferoen-Baert R, van der Valk P, et al.
Acta Neuropathol Commun
. 2015 Dec;
3:87.
PMID: 26694816
Introduction: The important protective role of small heat-shock proteins (HSPs) in regulating cellular survival and migration, counteracting protein aggregation, preventing apoptosis, and regulating inflammation in the central nervous system is...
10.
van Noort J, Bsibsi M, Nacken P, Verbeek R, Venneker E
PLoS One
. 2015 Nov;
10(11):e0143366.
PMID: 26599332
Unlabelled: As a molecular chaperone and activator of Toll-like receptor 2-mediated protective responses by microglia and macrophages, the small heat shock protein alpha B-crystallin (HspB5) exerts therapeutic effects in different...