Johannes Delp
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Explore the profile of Johannes Delp including associated specialties, affiliations and a list of published articles.
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22
Citations
244
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Recent Articles
1.
Eberhard P, Kern M, Aichem M, Borlinghaus H, Klein K, Delp J, et al.
Bioinformatics
. 2024 May;
40(6).
PMID: 38724240
Motivation: High-throughput omics methods increasingly result in large datasets including metabolomics data, which are often difficult to analyse. Results: To help researchers to handle and analyse those datasets by mapping...
2.
Suciu I, Delp J, Gutbier S, Suess J, Henschke L, Celardo I, et al.
Antioxidants (Basel)
. 2024 Jan;
13(1).
PMID: 38247474
To characterize the hits from a phenotypic neurotoxicity screen, we obtained transcriptomics data for valinomycin, diethylstilbestrol, colchicine, rotenone, 1-methyl-4-phenylpyridinium (MPP), carbaryl and berberine (Ber). For all compounds, the concentration triggering...
3.
Carta G, van der Stel W, Scuric E, Capinha L, Delp J, Bennekou S, et al.
Cell Biol Toxicol
. 2023 Jun;
39(6):3031-3059.
PMID: 37353587
Analysis of the transcriptomic alterations upon chemical challenge, provides in depth mechanistic information on the compound's toxic mode of action, by revealing specific pathway activation and other transcriptional modulations. Mapping...
4.
Suciu I, Delp J, Gutbier S, Uckert A, Spreng A, Eberhard P, et al.
Antioxidants (Basel)
. 2023 Jan;
12(1).
PMID: 36671027
Proteasome inhibition is associated with parkinsonian pathology in vivo and degeneration of dopaminergic neurons in vitro. We explored here the metabolome (386 metabolites) and transcriptome (3257 transcripts) regulations of human...
5.
Tebby C, Gao W, Delp J, Carta G, van der Stel W, Leist M, et al.
Toxicol In Vitro
. 2022 Mar;
81:105345.
PMID: 35278637
Adverse Outcome Pathways (AOPs) are increasingly used to support the integration of in vitro data in hazard assessment for chemicals. Quantitative AOPs (qAOPs) use mathematical models to describe the relationship...
6.
van der Stel W, Yang H, Vrijenhoek N, Schimming J, Callegaro G, Carta G, et al.
Arch Toxicol
. 2021 Oct;
96(1):259-285.
PMID: 34642769
Mitochondrial perturbation is a key event in chemical-induced organ toxicities that is incompletely understood. Here, we studied how electron transport chain (ETC) complex I, II, or III (CI, CII and...
7.
van der Stel W, Carta G, Eakins J, Delp J, Suciu I, Forsby A, et al.
ALTEX
. 2021 Jun;
38(4):615-635.
PMID: 34114044
Read-across approaches are considered key in moving away from in vivo animal testing towards addressing data-gaps using new approach methods (NAMs). Ample successful examples are still required to substantiate this...
8.
Delp J, Cediel-Ulloa A, Suciu I, Kranaster P, van Vugt-Lussenburg B, Munic Kos V, et al.
Arch Toxicol
. 2021 Jan;
95(2):591-615.
PMID: 33512557
Inhibition of complex I of the mitochondrial respiratory chain (cI) by rotenone and methyl-phenylpyridinium (MPP +) leads to the degeneration of dopaminergic neurons in man and rodents. To formally describe...
9.
Fuscaldi L, de Avelar Junior J, Santos D, Boff D, de Oliveira V, Gomes K, et al.
Exp Biol Med (Maywood)
. 2020 Nov;
246(4):414-425.
PMID: 33175610
In the continuing search for novel antibiotics, antimicrobial peptides are promising molecules, due to different mechanisms of action compared to classic antibiotics and to their selectivity for interaction with microorganism...
10.
van der Stel W, Carta G, Eakins J, Darici S, Delp J, Forsby A, et al.
Arch Toxicol
. 2020 Jul;
94(8):2731-2732.
PMID: 32720191
In the original publication of the article.