Johanna C Sierra
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Explore the profile of Johanna C Sierra including associated specialties, affiliations and a list of published articles.
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32
Citations
867
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Recent Articles
1.
McNamara K, Sierra J, Latour Y, Hawkins C, Asim M, Williams K, et al.
Oncogene
. 2024 Nov;
44(5):296-306.
PMID: 39523394
Helicobacter pylori is the primary cause of gastric cancer, and there is a need to discover new molecular targets for therapeutic intervention in H. pylori disease progression. We have previously...
2.
Latour Y, Sierra J, McNamara K, Smith T, Luis P, Schneider C, et al.
J Immunol
. 2022 Jul;
209(4):796-805.
PMID: 35896340
Colonization by is associated with gastric diseases, ranging from superficial gastritis to more severe pathologies, including intestinal metaplasia and adenocarcinoma. The interplay of the host response and the pathogen affect...
3.
Latour Y, Sierra J, Finley J, Asim M, Barry D, Allaman M, et al.
JCI Insight
. 2022 May;
7(12.
PMID: 35579952
Macrophages play a crucial role in the inflammatory response to the human stomach pathogen Helicobacter pylori, which infects half of the world's population and causes gastric cancer. Recent studies have...
4.
Gobert A, Latour Y, Asim M, Barry D, Allaman M, Finley J, et al.
Gastroenterology
. 2021 Nov;
162(3):813-827.e8.
PMID: 34767785
Background & Aims: Because inflammatory bowel disease is increasing worldwide and can lead to colitis-associated carcinoma (CAC), new interventions are needed. We have shown that spermine oxidase (SMOX), which generates...
5.
Gobert A, Finley J, Latour Y, Asim M, Smith T, Verriere T, et al.
Cell Rep
. 2020 Dec;
33(11):108510.
PMID: 33326776
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation...
6.
Gobert A, Boutaud O, Asim M, Zagol-Ikapitte I, Delgado A, Latour Y, et al.
Gastroenterology
. 2020 Nov;
160(4):1256-1268.e9.
PMID: 33189701
Background & Aims: Inflammation in the gastrointestinal tract may lead to the development of cancer. Dicarbonyl electrophiles, such as isolevuglandins (isoLGs), are generated from lipid peroxidation during the inflammatory response...
7.
Sierra J, Piazuelo M, Luis P, Barry D, Allaman M, Asim M, et al.
Oncogene
. 2020 May;
39(22):4465-4474.
PMID: 32350444
Helicobacter pylori infection is the main risk factor for the development of gastric cancer, the third leading cause of cancer death worldwide. H. pylori colonizes the human gastric mucosa and...
8.
Caston R, Sierra J, Foegeding N, Truelock M, Campbell A, Frick-Cheng A, et al.
Infect Immun
. 2020 Apr;
88(6).
PMID: 32284370
colonizes the gastric mucosa and secretes a pore-forming toxin (VacA). Two main types of VacA, m1 and m2, can be distinguished by phylogenetic analysis. Type m1 forms of VacA have...
9.
Gobert A, Latour Y, Asim M, Finley J, Verriere T, Barry D, et al.
mBio
. 2019 Oct;
10(5).
PMID: 31662455
The reverse transsulfuration pathway is the major route for the metabolism of sulfur-containing amino acids. The role of this metabolic pathway in macrophage response and function is unknown. We show...
10.
Sierra J, Suarez G, Piazuelo M, Luis P, Baker D, Romero-Gallo J, et al.
Proc Natl Acad Sci U S A
. 2019 Feb;
116(11):5077-5085.
PMID: 30804204
Infection by is the primary cause of gastric adenocarcinoma. The most potent virulence factor is cytotoxin-associated gene A (CagA), which is translocated by a type 4 secretion system (T4SS) into...