Joel H Nystrom
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Explore the profile of Joel H Nystrom including associated specialties, affiliations and a list of published articles.
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11
Citations
168
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Recent Articles
1.
Nystrom J, Heikkila T, Thapa K, Pulli I, Tornquist K, Toivola D
Am J Physiol Gastrointest Liver Physiol
. 2024 Jun;
327(3):G438-G453.
PMID: 38860856
Keratin intermediate filaments form dynamic filamentous networks, which provide mechanical stability, scaffolding, and protection against stress to epithelial cells. Keratins and other intermediate filaments have been increasingly linked to the...
2.
Cytoplasmic keratins couple with and maintain nuclear envelope integrity in colonic epithelial cells
Stenvall C, Nystrom J, Butler-Hallissey C, Jansson T, Heikkila T, Adam S, et al.
Mol Biol Cell
. 2022 Aug;
33(13):ar121.
PMID: 36001365
Keratin intermediate filaments convey mechanical stability and protection against stress to epithelial cells. Keratins are essential for colon health, as seen in keratin 8 knockout (K8) mice exhibiting a colitis...
3.
Polari L, Alam C, Nystrom J, Heikkila T, Tayyab M, Baghestani S, et al.
Int J Biochem Cell Biol
. 2020 Nov;
129:105878.
PMID: 33152513
Keratin intermediate filament proteins are major cytoskeletal components of the mammalian simple layered columnar epithelium in the gastrointestinal tract. Human colon crypt epithelial cells express keratins 18, 19 and 20...
4.
Helenius T, Antman C, Asghar M, Nystrom J, Toivola D
Cells
. 2016 Sep;
5(3).
PMID: 27626448
Keratin (K) intermediate filaments can be divided into type I/type II proteins, which form obligate heteropolymers. Epithelial cells express type I-type II keratin pairs, and K7, K8 (type II) and...
5.
Misiorek J, Lahdeniemi I, Nystrom J, Paramonov V, Gullmets J, Saarento H, et al.
Carcinogenesis
. 2016 May;
37(8):777-786.
PMID: 27234655
Keratins (K) are intermediate filament proteins important in protection from cellular stress. K8, K18 and K19 are the main components of keratin filaments in colonic epithelia but their role in...
6.
Asghar M, Priyamvada S, Nystrom J, Natarajan Anbazhagan A, Dudeja P, Toivola D
Am J Physiol Gastrointest Liver Physiol
. 2016 Apr;
310(11):G1147-54.
PMID: 27125276
Keratins (K) are intermediate filament proteins important in protection from stress. The roles of keratins in the intestine are not clear, but K8 knockout (K8(-/-)) mice develop a Th2-type colonic...
7.
Strnad P, Guldiken N, Helenius T, Misiorek J, Nystrom J, Lahdeniemi I, et al.
Methods Enzymol
. 2016 Jan;
568:351-88.
PMID: 26795477
Simple epithelial keratins (SEKs) are the cytoplasmic intermediate filament proteins of single-layered and glandular epithelial cells as found in the liver, pancreas, intestine, and lung. SEKs have broad cytoprotective functions,...
8.
Toivola D, Habtezion A, Misiorek J, Zhang L, Nystrom J, Sharpe O, et al.
FASEB J
. 2015 Sep;
29(12):5081-9.
PMID: 26399787
Human mutations in keratin 8 (K8) and keratin 18 (K18), the intermediate filament proteins of hepatocytes, predispose to several liver diseases. K8-null mice develop chronic liver injury and fragile hepatocytes,...
9.
Helenius T, Misiorek J, Nystrom J, Fortelius L, Habtezion A, Liao J, et al.
Mol Biol Cell
. 2015 Apr;
26(12):2298-310.
PMID: 25904331
Simple-type epithelial keratins are intermediate filament proteins important for mechanical stability and stress protection. Keratin mutations predispose to human liver disorders, whereas their roles in intestinal diseases are unclear. Absence...
10.
Nystrom J, Lonnfors M, Nyholm T
Biophys J
. 2010 Jul;
99(2):526-33.
PMID: 20643071
Cholesterol is distributed unevenly between different cellular membrane compartments, and the cholesterol content increases from the inner bilayers toward the plasma membrane. It has been suggested that this cholesterol gradient...