Joel D Boerckel
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Explore the profile of Joel D Boerckel including associated specialties, affiliations and a list of published articles.
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52
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1302
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Recent Articles
1.
Lang A, Collins J, Nijsure M, Belali S, Khan M, Moharrer Y, et al.
bioRxiv
. 2025 Jan;
PMID: 39829797
Bone fracture ruptures blood vessels and disrupts the bone marrow, the site of new red blood cell production (erythropoiesis). Current dogma holds that bone fracture causes severe hypoxia at the...
2.
Nijsure M, Tobin B, Jones D, Lang A, Hallstrom G, Baitner M, et al.
bioRxiv
. 2025 Jan;
PMID: 39764016
Bone fracture repair initiates by periosteal expansion. The periosteum is typically quiescent, but upon fracture, periosteal cells proliferate and contribute to bone fracture repair. The expansion of the periosteum is...
3.
Panebianco C, Essaidi M, Barnes E, Williams A, Vancikova K, Labberte M, et al.
bioRxiv
. 2025 Jan;
PMID: 39763848
Bones develop to structurally balance strength and mobility. Bone developmental dynamics are influenced by whether an animal is ambulatory at birth (, precocial). Precocial species, such as goats, develop advanced...
4.
Dufrancais O, Verdys P, Plozza M, Metais A, Juzans M, Sanchez T, et al.
bioRxiv
. 2024 May;
PMID: 38798563
Cell-cell fusion is an evolutionarily conserved process that is essential for many functions, including fertilisation and the formation of placenta, muscle and osteoclasts, multinucleated cells that are unique in their...
5.
Panebianco C, Nijsure M, Berlew E, Jeong A, Boerckel J
Biomed Eng Educ
. 2024 May;
4(1):73-86.
PMID: 38752167
Mechanobiology is an interdisciplinary field that aims to understand how physical forces impact biological systems. Enhancing our knowledge of mechanobiology has become increasingly important for understanding human disease and developing...
6.
Lang A, Eastburn E, Younesi M, Nijsure M, Siciliano C, Pranatharthi Haran A, et al.
bioRxiv
. 2024 Apr;
PMID: 38617208
Compromised vascular supply and insufficient neovascularization impede bone repair, increasing risk of non-union. Cyr61, Cysteine-rich angiogenic inducer of 61kD (also known as CCN1), is a matricellular growth factor that is...
7.
Lang A, Benn A, Collins J, Wolter A, Balcaen T, Kerckhofs G, et al.
Commun Biol
. 2024 Mar;
7(1):315.
PMID: 38480819
Skeletal development depends on coordinated angiogenesis and osteogenesis. Bone morphogenetic proteins direct bone formation in part by activating SMAD1/5 signaling in osteoblasts. However, the role of SMAD1/5 in skeletal endothelium...
8.
Thai V, Mierswa S, Griffin K, Boerckel J, Leach J
APL Bioeng
. 2024 Mar;
8(1):016116.
PMID: 38435468
Mesenchymal stromal cells (MSCs) are widely used in cell-based therapies and tissue regeneration for their potent secretome, which promotes host cell recruitment and modulates inflammation. Compared to monodisperse cells, MSC...
9.
Collins J, Lang A, Parisi C, Moharrer Y, Nijsure M, Thomas Kim J, et al.
Dev Cell
. 2023 Dec;
59(2):211-227.e5.
PMID: 38141609
Fetal bone development occurs through the conversion of avascular cartilage to vascularized bone at the growth plate. This requires coordinated mobilization of osteoblast precursors with blood vessels. In adult bone,...
10.
Yao L, Lu J, Zhong L, Wei Y, Gui T, Wang L, et al.
Elife
. 2023 Dec;
12.
PMID: 38079220
Insufficient bone fracture repair represents a major clinical and societal burden and novel strategies are needed to address it. Our data reveal that the transforming growth factor-β superfamily member Activin...