Joe Z Zhang
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Explore the profile of Joe Z Zhang including associated specialties, affiliations and a list of published articles.
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32
Citations
798
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Recent Articles
1.
Liu C, Shen M, Liu Y, Manhas A, Zhao S, Zhang M, et al.
Cell Stem Cell
. 2024 Nov;
31(12):1760-1776.e9.
PMID: 39515331
Doxorubicin is limited in its therapeutic utility due to its life-threatening cardiovascular side effects. Here, we present an integrated drug discovery pipeline combining human induced pluripotent stem cell (iPSC)-derived cardiomyocytes...
2.
Yang H, Yang Y, Lu Z, Zhang J
Curr Protoc
. 2024 Jul;
4(7):e1101.
PMID: 38980221
Cardiovascular diseases have emerged as one of the leading causes of human mortality, but the discovery of new drugs has been hindered by the absence of suitable in vitro platforms....
3.
Kiskin F, Yang Y, Yang H, Zhang J
J Mol Cell Cardiol
. 2024 May;
192:65-78.
PMID: 38761989
Endothelial dysfunction is a central contributor to the development of most cardiovascular diseases and is characterised by the reduced synthesis or bioavailability of the vasodilator nitric oxide together with other...
4.
Yang Y, Yang H, Kiskin F, Zhang J
Med Rev (2021)
. 2024 Mar;
4(1):68-85.
PMID: 38515776
Cardiovascular research has heavily relied on studies using patient samples and animal models. However, patient studies often miss the data from the crucial early stage of cardiovascular diseases, as obtaining...
5.
Ji X, Chen Z, Wang Q, Li B, Wei Y, Li Y, et al.
Cell Metab
. 2024 Feb;
36(4):839-856.e8.
PMID: 38367623
Utilization of lipids as energy substrates after birth causes cardiomyocyte (CM) cell-cycle arrest and loss of regenerative capacity in mammalian hearts. Beyond energy provision, proper management of lipid composition is...
6.
Belbachir N, Wu Y, Shen M, Zhang S, Zhang J, Liu C, et al.
Circulation
. 2023 Nov;
148(20):1598-1601.
PMID: 37956223
No abstract available.
7.
Yang H, Yang Y, Kiskin F, Shen M, Zhang J
Stem Cell Res Ther
. 2023 Aug;
14(1):228.
PMID: 37649113
In the last decade, human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM)-based cell therapy has drawn broad attention as a potential therapy for treating injured hearts. However, mass production of hiPSC-CMs remains...
8.
Eguchi A, Gonzalez A, Torres-Bigio S, Koleckar K, Birnbaum F, Zhang J, et al.
Proc Natl Acad Sci U S A
. 2023 Jan;
120(6):e2209967120.
PMID: 36719921
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disease caused by the lack of dystrophin. Heart failure, driven by cardiomyocyte death, fibrosis, and the development of dilated cardiomyopathy, is...
9.
Ye S, Wang C, Xu Z, Lin H, Wan X, Yu Y, et al.
Circ Res
. 2022 Dec;
132(2):187-204.
PMID: 36583388
Background: pathogenic variants are implicated in multiple types of congenital heart defects including hypoplastic left heart syndrome, where the left ventricle is underdeveloped. It is unknown how regulates human cardiac...
10.
Zhang J, Zhao S, Tu C, Pang P, Zhang M, Wu J
STAR Protoc
. 2021 Nov;
2(4):100859.
PMID: 34746854
Multiple strategies have been developed to efficiently differentiate human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Here, we describe a protocol for measuring three key functional parameters of hiPSC-CMs, including contractile function,...