Joao Wosniak Jr
Overview
Explore the profile of Joao Wosniak Jr including associated specialties, affiliations and a list of published articles.
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7
Citations
293
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Recent Articles
1.
PDIA1 acts as master organizer of NOX1/NOX4 balance and phenotype response in vascular smooth muscle
Fernandes D, Wosniak Jr J, Goncalves R, Tanaka L, Fernandes C, Zanatta D, et al.
Free Radic Biol Med
. 2020 Nov;
162:603-614.
PMID: 33227407
Changes in vascular smooth muscle cell (VSMC) phenotype underlie disease pathophysiology and are strongly regulated by NOX NADPH oxidases, with NOX1 favoring synthetic proliferative phenotype and NOX4 supporting differentiation. Growth...
2.
Kajihara D, Hon C, Abdullah A, Wosniak Jr J, Moretti A, Poloni J, et al.
BMC Genomics
. 2020 Nov;
21(1):766.
PMID: 33148170
Background: Protein Disulfide Isomerases are thiol oxidoreductase chaperones from thioredoxin superfamily with crucial roles in endoplasmic reticulum proteostasis, implicated in many diseases. The family prototype PDIA1 is also involved in...
3.
Moretti A, Pavanelli J, Nolasco P, Leisegang M, Tanaka L, Fernandes C, et al.
Sci Rep
. 2017 Dec;
7(1):17262.
PMID: 29222525
Protein disulfide isomerases (PDIs) support endoplasmic reticulum redox protein folding and cell-surface thiol-redox control of thrombosis and vascular remodeling. The family prototype PDIA1 regulates NADPH oxidase signaling and cytoskeleton organization,...
4.
Fernandes D, Manoel A, Wosniak Jr J, Laurindo F
Arch Biochem Biophys
. 2009 Apr;
484(2):197-204.
PMID: 19402212
Mechanisms regulating NADPH oxidase remain open and include the redox chaperone protein disulfide isomerase (PDI). Here, we further investigated PDI effects on vascular NADPH oxidase. VSMC transfected with wild-type PDI...
5.
Wosniak Jr J, Santos C, Kowaltowski A, Laurindo F
Antioxid Redox Signal
. 2009 Mar;
11(6):1265-78.
PMID: 19281299
Mitochondria and NADPH oxidase activation are concomitantly involved in pathogenesis of many vascular diseases. However, possible cross-talk between those ROS-generating systems is unclear. We induced mild mitochondrial dysfunction due to...
6.
Liberman M, Bassi E, Martinatti M, Lario F, Wosniak Jr J, Pomerantzeff P, et al.
Arterioscler Thromb Vasc Biol
. 2007 Dec;
28(3):463-70.
PMID: 18162610
Objective: We hypothesized that reactive oxygen species (ROS) contribute to progression of aortic valve (AV) calcification/stenosis. Methods And Results: We investigated ROS production and effects of antioxidants tempol and lipoic...
7.
Fernandes D, Wosniak Jr J, Pescatore L, Bertoline M, Liberman M, Laurindo F, et al.
Am J Physiol Cell Physiol
. 2006 Sep;
292(1):C413-22.
PMID: 16971501
Dihydroethidium (DHE) is a widely used sensitive superoxide (O2(*-)) probe. However, DHE oxidation yields at least two fluorescent products, 2-hydroxyethidium (EOH), known to be more specific for O2(*-), and the...