Joao Laranjinha
Overview
Explore the profile of Joao Laranjinha including associated specialties, affiliations and a list of published articles.
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81
Citations
1132
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Recent Articles
1.
Dias C, Lourenco C, Laranjinha J, Ledo A
Methods Mol Biol
. 2024 Nov;
2878():35-48.
PMID: 39546255
The brain is critically dependent on energetic substrates as it consumes circa 20% of glucose and oxygen under normal physiological conditions. Although different cell types and at different locations might...
2.
Paiva B, Laranjinha J, Rocha B
FEBS Lett
. 2024 Mar;
598(17):2211-2223.
PMID: 38523057
Nitrate may act as a regulator of NO bioavailability via sequential reduction along the nitrate-nitrite-NO pathway with widespread health benefits, including a eubiotic effect on the oral and gut microbiota....
3.
Goncalves J, Marcal A, Marques B, Costa F, Laranjinha J, Rocha B, et al.
Biochem Soc Trans
. 2024 Feb;
52(1):279-289.
PMID: 38385536
Diet is currently recognized as a major modifiable agent of human health. In particular, dietary nitrate has been increasingly explored as a strategy to modulate different physiological mechanisms with demonstrated...
4.
Reis A, Rocha B, Laranjinha J, de Freitas V
FEBS Lett
. 2024 Jan;
598(17):2190-2210.
PMID: 38281810
Hypertension is a major contributor to premature death, owing to the associated increased risk of damage to the heart, brain and kidneys. Although hypertension is manageable by medication and lifestyle...
5.
Dias C, Fernandes E, Barbosa R, Laranjinha J, Ledo A
Biofactors
. 2023 Apr;
49(4):875-886.
PMID: 37070143
Under physiological conditions, the energetic demand of the brain is met by glucose oxidation. However, ample evidence suggests that lactate produced by astrocytes through aerobic glycolysis may also be an...
6.
Reva K, Laranjinha J, Rocha B
Metabolites
. 2023 Mar;
13(3).
PMID: 36984815
Diet is currently considered one of the most important adjustable determinants of human health. The gut microbiota, the collection of microorganisms that inhabit (mainly) the distal bowel, has recently been...
7.
Fraga C, Trostchansky A, Rocha B, Laranjinha J, Rubbo H, Galleano M
Mol Aspects Med
. 2022 Dec;
89:101158.
PMID: 36517273
Nitric oxide (NO) is an essential molecule able to control and regulate many biological functions. Additionally, NO bears a potential toxicity or damaging effects under conditions of uncontrolled production, and...
8.
Goncalves J, Seica R, Laranjinha J, Lourenco C
Free Radic Biol Med
. 2022 Nov;
193(Pt 2):669-675.
PMID: 36372286
Numerous epidemiological and preclinical studies have established a strong correlation between type 2 diabetes (T2DM) and cognitive impairment and T2DM is now established as an undisputable risk factor in different...
9.
Lourenco C, Laranjinha J
Front Physiol
. 2021 Nov;
12:729201.
PMID: 34744769
The brain has impressive energy requirements and paradoxically, very limited energy reserves, implying its huge dependency on continuous blood supply. Aditionally, cerebral blood flow must be dynamically regulated to the...
10.
Mancini G, Dias C, Lourenco C, Laranjinha J, De Bem A, Ledo A
J Alzheimers Dis
. 2021 Jul;
82(4):1619-1633.
PMID: 34219714
Background: Ample evidence from clinical and pre-clinical studies suggests mid-life hypercholesterolemia as a risk factor for developing Alzheimer's disease (AD) at a later age. Hypercholesterolemia induced by dietary habits can...