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Joanna Giles

Explore the profile of Joanna Giles including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
1.
Giles J, Roberts A
Adv Protein Chem Struct Biol . 2022 Mar; 129:215-245. PMID: 35305720
The most common world-wide cause of antibiotic-associated infectious diarrhea and colitis is the toxin producing bacterium, Clostridioides difficile (C. difficile). Here we review the background and characteristics of the bacterium...
2.
Roberts A, Harris H, Smith M, Giles J, Polak O, Buckley A, et al.
Front Microbiol . 2020 Oct; 11:578903. PMID: 33072047
infection (CDI) is a toxin-mediated infection in the gut and a major burden on healthcare facilities worldwide. We rationalized that it would be beneficial to design an antibody therapy that...
3.
Cauli A, Shaw J, Giles J, Hatano H, Rysnik O, Payeli S, et al.
Rheumatology (Oxford) . 2013 Jun; 52(11):1952-62. PMID: 23804219
Objectives: HLA-B*27:05 is associated with AS whereas HLA-B*27:09 is not associated. We hypothesized that different interactions with KIR immune receptors could contribute to the difference in disease association between HLA-B*27:05...
4.
Giles J, Shaw J, Piper C, Wong-Baeza I, McHugh K, Ridley A, et al.
J Immunol . 2012 May; 188(12):6184-93. PMID: 22593621
Possession of HLA-B27 (B27) strongly predisposes to the development of spondyloarthritis. B27 forms classical heterotrimeric complexes with β(2)-microglobulin (β2m) and peptide and (β2m free) free H chain (FHC) forms including...
5.
Payeli S, Kollnberger S, Belaunzaran O, Thiel M, McHugh K, Giles J, et al.
Arthritis Rheum . 2012 May; 64(10):3139-49. PMID: 22576154
Objective: Spondylarthritides (SpA), including ankylosing spondylitis (AS), are common inflammatory rheumatic diseases that are strongly associated with positivity for the HLA class I allotype B27. HLA-B27 normally forms complexes with...