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Joan Villena

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Articles 44
Citations 289
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Recent Articles
1.
Silva V, Munoz E, Ferreira C, Russo A, Villena J, Montenegro I, et al.
Int J Mol Sci . 2025 Mar; 26(5). PMID: 40076860
This study investigates the anticancer potential of isocordoin, a prenylated chalcone found in . In vitro assays on colorectal (HT-29), breast (MCF-7) and prostate (PC-3) cancer cell lines, together with...
2.
Martinez-Lobos M, Silva V, Villena J, Jara-Gutierrez C, Vera Quezada W, Montenegro I, et al.
Plants (Basel) . 2024 Nov; 13(21). PMID: 39519908
Mol. is a plant of the Bromeliaceae family, which has been traditionally used for medicinal applications in various digestive disorders. In this study, the phytoconstituents of six extracts of stems...
3.
Faundes-Gandolfo N, Jara-Gutierrez C, Parraga M, Montenegro I, Vera W, Escobar M, et al.
BMC Complement Med Ther . 2024 Jul; 24(1):269. PMID: 39010075
Background: The leaves of Kalanchoe pinnata (Lam.) Pers. (K. pinnata), a succulent plant native to tropical regions, are used as a medicinal alternative against cancer in several countries worldwide; however,...
4.
Martinez-Lobos M, Tapia-Venegas E, Celis-Pla P, Villena J, Jara-Gutierrez C, Lobos-Pessini A, et al.
Int J Mol Sci . 2024 Jun; 25(11). PMID: 38892183
Hook. & Arn (Asteraceae), commonly known as Vautro, is found in the coastal areas of central-southern Chile, including the industrial zone of Quintero-Puchuncaví, known for the contamination of its soils...
5.
Arrieche D, Olea A, Jara-Gutierrez C, Villena J, Pardo-Baeza J, Garcia-Davis S, et al.
Plants (Basel) . 2024 May; 13(10). PMID: 38794478
is a shrub with yellow flowers that reach up to two meters high, endemic of the Atacama Region in Chile. This species grows under special environmental conditions such as low...
6.
Jara-Gutierrez C, Mercado L, Paz-Araos M, Howard C, Parraga M, Escobar C, et al.
BMC Complement Med Ther . 2024 Jan; 24(1):38. PMID: 38218817
Background: Standard cancer treatments show a lack of selectivity that has led to the search for new strategies against cancer. The selective elimination of cancer cells modulating the redox environment,...
7.
Martinez-Lobos M, Tapia-Venegas E, Celis-Pla P, Villena J, Jara-Gutierrez C, Lobos Pessini A, et al.
Molecules . 2023 Oct; 28(20). PMID: 37894517
, an endemic plant in Chile, is highly regarded for its medicinal properties and is popular in alternative medicine. It thrives even in polluted areas, like Puchuncaví Valley, Chile. Therefore,...
8.
Pino S, Espinoza L, Jara-Gutierrez C, Villena J, Olea A, Diaz K
Plants (Basel) . 2023 May; 12(9). PMID: 37176831
Currently, much effort is being placed into obtaining extracts and/or essential oils from L. for specific therapeutic purposes or pharmacological compositions. These potential applications depend mainly on the phytochemical composition...
9.
Araque I, Ramirez J, Vergara R, Mella J, Aranguiz P, Espinoza L, et al.
Molecules . 2023 May; 28(9). PMID: 37175368
In this study, we aimed to evaluate two sets of sesquiterpene-aryl derivatives linked by an ester bond, their cytotoxic activities, and their capacity to activate caspases 3/7 and inhibit human...
10.
Carrasco N, Garrido M, Montenegro I, Madrid A, Hartley R, Gonzalez I, et al.
Int J Mol Sci . 2023 Jan; 24(2). PMID: 36674960
is a native South American plant used ancestrally by Mapuche people to treat gastrointestinal ailments. flower extracts are rich in molecules with therapeutic potential, including the sesquiterpene lactone leptocarpin, which...