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Joan Vera-Villalobos

Explore the profile of Joan Vera-Villalobos including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 15
Followers 0
Related Specialties
Biology
General Medicine
Biochemistry
Top 10 Co-Authors
Carla Lossada
Lenin Gonzalez-Paz
Maria Laura Hurtado-Leon
Ysaias J Alvarado
Marcos Lorono
J L Paz
Yovani Marrero-Ponce
Laura N Jeffreys
Laura Jeffreys
Jose Luis Paz
Published In
J Mol Liq
Comput Biol Chem
Biology (Basel)
Biophys Chem
Int J Biol Macromol
Affiliations
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Recent Articles
1.
Biological Implications of the Intrinsic Deformability of Human Acetylcholinesterase Induced by Diverse Compounds: A Computational Study
Alvarado Y, Gonzalez-Paz L, Paz J, Lorono-Gonzalez M, Santiago Contreras J, Lossada C, et al.
Biology (Basel) . 2025 Jan; 13(12. PMID: 39765732
The enzyme acetylcholinesterase (AChE) plays a crucial role in the termination of nerve impulses by hydrolyzing the neurotransmitter acetylcholine (ACh). The inhibition of AChE has emerged as a promising therapeutic...
2.
Biophysical Analysis of Potential Inhibitors of SARS-CoV-2 Cell Recognition and Their Effect on Viral Dynamics in Different Cell Types: A Computational Prediction from In Vitro Experimental Data
Gonzalez-Paz L, Lossada C, Hurtado-Leon M, Vera-Villalobos J, Paz J, Marrero-Ponce Y, et al.
ACS Omega . 2024 Mar; 9(8):8923-8939. PMID: 38434903
Recent reports have suggested that the susceptibility of cells to SARS-CoV-2 infection can be influenced by various proteins that potentially act as receptors for the virus. To investigate this further,...
3.
Macromolecular crowding impact on anti-CRISPR AcrIIC3/NmeCas9 complex: Insights from scaled particle theory, molecular dynamics, and elastic networks models
Delgado A, Vera-Villalobos J, Paz J, Lossada C, Hurtado-Leon M, Marrero-Ponce Y, et al.
Int J Biol Macromol . 2023 May; 244:125113. PMID: 37257544
The coupling of Cas9 and its inhibitor AcrIIC3, both from the bacterium Neisseria meningitidis (Nme), form a homodimer of the (NmeCas9/AcrIIC3) type. This coupling was studied to assess the impact...
4.
Interaction of the new inhibitor paxlovid (PF-07321332) and ivermectin with the monomer of the main protease SARS-CoV-2: A volumetric study based on molecular dynamics, elastic networks, classical thermodynamics and SPT
Alvarado Y, Olivarez Y, Lossada C, Vera-Villalobos J, Paz J, Vera E, et al.
Comput Biol Chem . 2022 May; 99:107692. PMID: 35640480
The COVID-19 pandemic has accelerated the study of drugs, most notably ivermectin and more recently Paxlovid (PF-07321332) which is in phase III clinical trials with experimental data showing covalent binding...
5.
Comparative study of SARS-CoV-2 infection in different cell types: Biophysical-computational approach to the role of potential receptors
Gonzalez-Paz L, Alvarado M, Hurtado-Leon M, Lossada C, Vera-Villalobos J, Lorono M, et al.
Comput Biol Med . 2022 Jan; 142:105245. PMID: 35077937
Cellular susceptibility to SARS-CoV-2 infection in the respiratory tract has been associated with the ability of the virus to interact with potential receptors on the host membrane. We have modeled...
6.
Comparative study of the interaction of ivermectin with proteins of interest associated with SARS-CoV-2: A computational and biophysical approach
Gonzalez-Paz L, Hurtado-Leon M, Lossada C, Fernandez-Materan F, Vera-Villalobos J, Lorono M, et al.
Biophys Chem . 2021 Aug; 278:106677. PMID: 34428682
The SARS-CoV-2 pandemic has accelerated the study of existing drugs. The mixture of homologs called ivermectin (avermectin-B1a [HB1a] + avermectin-B1b [HB1b]) has shown antiviral activity against SARS-CoV-2 in vitro. However,...
7.
Structural deformability induced in proteins of potential interest associated with COVID-19 by binding of homologues present in ivermectin: Comparative study based in elastic networks models
Gonzalez-Paz L, Hurtado-Leon M, Lossada C, Fernandez-Materan F, Vera-Villalobos J, Lorono M, et al.
J Mol Liq . 2021 Aug; 340:117284. PMID: 34421159
The COVID-19 pandemic has accelerated the study of the potential of multi-target drugs (MTDs). The mixture of homologues called ivermectin (avermectin-B1a + avermectin-B1b) has been shown to be a MTD...