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Joan H Carter

Explore the profile of Joan H Carter including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 62
Followers 0
Related Specialties
Chemistry
Pharmacology
Neurology
Top 10 Co-Authors
Beverly A Heinz
Junliang Hao
James A Monn
Steven Swanson
Bryan G Johnson
Xushan Wang
David L McKinzie
John T Catlow
Steven S Henry
Frances Lu
Published In
J Med Chem
Neuropharmacology
Mol Pharmacol
Affiliations
Soon will be listed here.
Recent Articles
1.
Intracellular Binding Site for a Positive Allosteric Modulator of the Dopamine D1 Receptor
Wang X, Heinz B, Qian Y, Carter J, Gadski R, Beavers L, et al.
Mol Pharmacol . 2018 Aug; 94(4):1232-1245. PMID: 30111649
The binding site for DETQ [2-(2,6-dichlorophenyl)-1-((1,3)-3-(hydroxymethyl)-5-(2-hydroxypropan-2-yl)-1-methyl-3,4-dihydroisoquinolin-2(1)-yl)ethan-1-one], a positive allosteric modulator (PAM) of the dopamine D1 receptor, was identified and compared with the binding site for CID 2886111 [-(6--butyl-3-carbamoyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)pyridine-4-carboxamide], a reference...
2.
Synthesis and Pharmacological Characterization of C4-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193),...
Monn J, Henry S, Massey S, Clawson D, Chen Q, Diseroad B, et al.
J Med Chem . 2018 Jan; 61(6):2303-2328. PMID: 29350927
Multiple therapeutic opportunities have been suggested for compounds capable of selective activation of metabotropic glutamate 3 (mGlu) receptors, but small molecule tools are lacking. As part of our ongoing efforts...
3.
In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu receptor antagonist
Witkin J, Ornstein P, Mitch C, Li R, Smith S, Heinz B, et al.
Neuropharmacology . 2016 Jan; 115:100-114. PMID: 26748052
Metabotropic glutamate (mGlu) receptors are of considerable interest owing to their role in modulating glutamate transmission via presynaptic, postsynaptic and glial mechanisms. As part of our ongoing efforts to identify...
4.
Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid...
Monn J, Prieto L, Taboada L, Hao J, Reinhard M, Henry S, et al.
J Med Chem . 2015 Aug; 58(18):7526-48. PMID: 26313429
Identification of orthosteric mGlu(2/3) receptor agonists capable of discriminating between individual mGlu2 and mGlu3 subtypes has been highly challenging owing to the glutamate-site sequence homology between these proteins. Herein we...
5.
Synthesis and pharmacological characterization of C4-disubstituted analogs of 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: identification of a potent, selective metabotropic glutamate receptor agonist and determination of agonist-bound...
Monn J, Prieto L, Taboada L, Pedregal C, Hao J, Reinhard M, et al.
J Med Chem . 2015 Jan; 58(4):1776-94. PMID: 25602126
As part of our ongoing research to identify novel agents acting at metabotropic glutamate 2 (mGlu2) and 3 (mGlu3) receptors, we have previously reported the identification of the C4α-methyl analog...
6.
Synthesis and pharmacological characterization of 4-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: identification of new potent and selective metabotropic glutamate 2/3 receptor agonists
Monn J, Valli M, Massey S, Hao J, Reinhard M, Bures M, et al.
J Med Chem . 2013 May; 56(11):4442-55. PMID: 23675965
As part of our ongoing interest in identifying novel agonists acting at metabotropic glutamate (mGlu) 2/3 receptors, we have explored the effect of structural modifications of 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740), a potent...