Joachim Pircher
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Explore the profile of Joachim Pircher including associated specialties, affiliations and a list of published articles.
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51
Citations
1160
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Recent Articles
1.
Anjum A, Mader M, Mahameed S, Muraly A, Denorme F, Kliem F, et al.
Blood
. 2025 Jan;
PMID: 39841014
Platelets are crucial players in hemostasis and thrombosis, but also contribute to immune regulation and host defense, using different receptors, signaling pathways and effector functions, respectively. Whether distinct subsets of...
2.
Diehl C, Soberon V, Baygun S, Chu Y, Mandelbaum J, Kraus L, et al.
Immunity
. 2024 Dec;
58(1):124-142.e15.
PMID: 39729992
B cell immunity carries the inherent risk of deviating into autoimmunity and malignancy, which are both strongly associated with genetic variants or alterations that increase immune signaling. Here, we investigated...
3.
Arenz L, Porger A, De Michel M, Weber A, Jung J, Horns H, et al.
JAC Antimicrob Resist
. 2024 Feb;
6(1):dlae026.
PMID: 38410248
Objectives: To explore effectiveness and sustainability of guideline adherence and antibiotic consumption after establishing treatment guidelines and initiating antimicrobial stewardship (AMS) ward rounds in a university hospital emergency department (ED)....
4.
Liu W, Pircher J, Schuermans A, Ain Q, Zhang Z, Honigberg M, et al.
Blood
. 2023 Dec;
143(15):1539-1550.
PMID: 38142422
JAK2 V617F (JAK2VF) clonal hematopoiesis (CH) has been associated with atherothrombotic cardiovascular disease (CVD). We assessed the impact of Jak2VF CH on arterial thrombosis and explored the underlying mechanisms. A...
5.
Zhang Q, Ain Q, Schulz C, Pircher J
Front Immunol
. 2023 Apr;
14:1151926.
PMID: 37090695
Thrombosis is a frequent cause of cardiovascular mortality and hospitalization. Current antithrombotic strategies, however, target both thrombosis and physiological hemostasis and thereby increase bleeding risk. In recent years the pathophysiological...
6.
Neutrophil "plucking" on megakaryocytes drives platelet production and boosts cardiovascular disease
Petzold T, Zhang Z, Ballesteros I, Saleh I, Polzin A, Thienel M, et al.
Immunity
. 2022 Oct;
55(12):2285-2299.e7.
PMID: 36272416
Intravascular neutrophils and platelets collaborate in maintaining host integrity, but their interaction can also trigger thrombotic complications. We report here that cooperation between neutrophil and platelet lineages extends to the...
7.
Nicolai L, Schiefelbein K, Lipsky S, Leunig A, Hoffknecht M, Pekayvaz K, et al.
Nat Commun
. 2022 Aug;
13(1):4645.
PMID: 35941111
No abstract available.
8.
Single platelet and megakaryocyte morpho-dynamics uncovered by multicolor reporter mouse strains and
Nicolai L, Kaiser R, Escaig R, Hoffknecht M, Anjum A, Leunig A, et al.
Haematologica
. 2021 Sep;
107(7):1669-1680.
PMID: 34525794
Visualizing cell behavior and effector function on a single cell level has been crucial for understanding key aspects of mammalian biology. Due to their small size, large number and rapid...
9.
Fidler T, Xue C, Yalcinkaya M, Hardaway B, Abramowicz S, Xiao T, et al.
Nature
. 2021 Mar;
592(7853):296-301.
PMID: 33731931
Clonal haematopoiesis, which is highly prevalent in older individuals, arises from somatic mutations that endow a proliferative advantage to haematopoietic cells. Clonal haematopoiesis increases the risk of myocardial infarction and...
10.
Nicolai L, Schiefelbein K, Lipsky S, Leunig A, Hoffknecht M, Pekayvaz K, et al.
Nat Commun
. 2020 Nov;
11(1):5778.
PMID: 33188196
Breakdown of vascular barriers is a major complication of inflammatory diseases. Anucleate platelets form blood-clots during thrombosis, but also play a crucial role in inflammation. While spatio-temporal dynamics of clot...