Joachim J Li
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Explore the profile of Joachim J Li including associated specialties, affiliations and a list of published articles.
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9
Citations
303
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Recent Articles
1.
Bui D, Li J
Genetics
. 2019 Apr;
212(2):445-460.
PMID: 31028114
The sources of genome instability, a hallmark of cancer, remain incompletely understood. One potential source is DNA rereplication, which arises when the mechanisms that prevent the reinitiation of replication origins...
2.
Hanlon S, Li J
PLoS Genet
. 2015 Apr;
11(4):e1005039.
PMID: 25901968
The faithful inheritance of chromosomes during cell division requires their precise replication and segregation. Numerous mechanisms ensure that each of these fundamental cell cycle events is performed with a high...
3.
Richardson C, Li J
PLoS Genet
. 2014 Jun;
10(6):e1004358.
PMID: 24945837
Eukaryotic cells must inhibit re-initiation of DNA replication at each of the thousands of origins in their genome because re-initiation can generate genomic alterations with extraordinary frequency. To minimize the...
4.
Finn K, Li J
PLoS Genet
. 2013 Jan;
9(1):e1003192.
PMID: 23300490
Copy number expansions such as amplifications and duplications contribute to human phenotypic variation, promote molecular diversification during evolution, and drive the initiation and/or progression of various cancers. The mechanisms underlying...
5.
Green B, Finn K, Li J
Science
. 2010 Aug;
329(5994):943-6.
PMID: 20724634
Eukaryotic cells use numerous mechanisms to ensure that no segment of their DNA is inappropriately re-replicated, but the importance of this stringent control on genome stability has not been tested....
6.
Moses A, Liku M, Li J, Durbin R
Proc Natl Acad Sci U S A
. 2007 Nov;
104(45):17713-8.
PMID: 17978194
Evolutionary change in gene regulation is a key mechanism underlying the genetic component of organismal diversity. Here, we study evolution of regulation at the posttranslational level by examining the evolution...
7.
Green B, Morreale R, Ozaydin B, DeRisi J, Li J
Mol Biol Cell
. 2006 Feb;
17(5):2401-14.
PMID: 16481397
To maintain genomic stability, reinitiation of eukaryotic DNA replication within a single cell cycle is blocked by multiple mechanisms that inactivate or remove replication proteins after G1 phase. Consistent with...
8.
Liku M, Nguyen V, Rosales A, Irie K, Li J
Mol Biol Cell
. 2005 Aug;
16(10):5026-39.
PMID: 16093348
Cyclin-dependent kinases (CDKs) use multiple mechanisms to block reassembly of prereplicative complexes (pre-RCs) at replication origins to prevent inappropriate rereplication. In Saccharomyces cerevisiae, one of these mechanisms promotes the net...
9.
Green B, Li J
Mol Biol Cell
. 2004 Nov;
16(1):421-32.
PMID: 15537702
To maintain genome stability, the entire genome of a eukaryotic cell must be replicated once and only once per cell cycle. In many organisms, multiple overlapping mechanisms block rereplication, but...