Joab Chapman
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Explore the profile of Joab Chapman including associated specialties, affiliations and a list of published articles.
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Articles
167
Citations
2021
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Recent Articles
11.
Golderman V, Goldberg Z, Gofrit S, Dori A, Maggio N, Chapman J, et al.
Int J Mol Sci
. 2023 Feb;
24(3).
PMID: 36768341
Diabetic encephalopathy (DE) is an inflammation-associated diabetes mellitus (DM) complication. Inflammation and coagulation are linked and are both potentially modulated by inhibiting the thrombin cellular protease-activated receptor 1 (PAR1). Our...
12.
Goldman A, Raschi E, Chapman J, Santomasso B, Pasquini M, Perales M, et al.
Blood
. 2022 Nov;
141(6):673-677.
PMID: 36332168
No abstract available.
13.
Berkowitz S, Gofrit S, Aharoni S, Golderman V, Qassim L, Goldberg Z, et al.
Int J Mol Sci
. 2022 Sep;
23(18).
PMID: 36142385
Background. Due to the interactions between neuroinflammation and coagulation, the neural effects of lipopolysaccharide (LPS)-induced inflammation (1 mg/kg, intraperitoneal (IP), n = 20) and treatment with the anti-thrombotic enoxaparin (1...
14.
Menendez L, Milo R, Cohen O, Chapman J, Rosenmann H, Nitsan Z, et al.
Acta Neurol Scand
. 2022 Aug;
146(5):586-589.
PMID: 35974683
Background: The largest cluster of genetic Creutzfeldt- Jakob Disease (CJD) exists in Libyan Jews carrying the E200K mutation in the PRNP gene. However, there is another cluster of genetic CJD...
15.
Thrombin Activity in Rodent and Human Skin: Modified by Inflammation and Correlates with Innervation
Golderman V, Berkowitz S, Guly Gofrit S, Gera O, Aharoni S, Zohar D, et al.
Biomedicines
. 2022 Jun;
10(6).
PMID: 35740482
Thrombin is present in peripheral nerves and is involved in the pathogenesis of neuropathy. We evaluated thrombin activity in skin punch biopsies taken from the paws of male mice and...
16.
Golderman V, Ben-Shimon M, Maggio N, Dori A, Gofrit S, Berkowitz S, et al.
J Neuroinflammation
. 2022 Jun;
19(1):138.
PMID: 35690769
Background: Inflammation and coagulation are linked and pathogenic in neuroinflammatory diseases. Protease-activated receptor 1 (PAR1) can be activated both by thrombin, inducing increased inflammation, and activated protein C (aPC), inducing...
17.
Zmira O, Gofrit S, Aharoni S, Weiss R, Shavit-Stein E, Chapman J
Lupus
. 2022 May;
31(7):855-863.
PMID: 35575144
Antiphospholipid syndrome (APS) affects the brain by both hypercoagulation and immunological mechanisms. APS is characterized by several autoantibodies binding to a thrombolytic complex including beta-2-glycoprotein I (β2-GPI) and annexin A2...
18.
Trachtenbroit I, Cohen O, Chapman J, Rosenmann H, Nitsan Z, Kahana E, et al.
Neurol Sci
. 2022 Mar;
43(7):4275-4279.
PMID: 35257261
Background: Creutzfeldt-Jacob disease (CJD) is a fatal neuro-degenerative disease, characterized by rapid and intense deterioration, mainly cognitive, leading to death. The typical onset of the disease is around the age...
19.
Goldberg Z, Sher I, Qassim L, Chapman J, Rotenstreich Y, Shavit-Stein E
Int J Mol Sci
. 2022 Jan;
23(2).
PMID: 35055169
The aim of this study was to characterize the distribution of the thrombin receptor, protease activated receptor 1 (PAR1), in the neuroretina. Neuroretina samples of wild-type C57BL/6J and PAR1 mice...
20.
Aharoni R, Eilam R, Lerner S, Shavit-Stein E, Dori A, Chapman J, et al.
Int J Mol Sci
. 2021 Dec;
22(24).
PMID: 34948217
Axonal and neuronal pathologies are a central constituent of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), induced by the myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide. In...