Jo L M R Leroy
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Explore the profile of Jo L M R Leroy including associated specialties, affiliations and a list of published articles.
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56
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589
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Recent Articles
1.
Marei W, Moorkens K, Gansemans Y, Van Nieuwerburgh F, Leroy J
Biol Reprod
. 2025 Feb;
PMID: 39913328
Diet-induced obesity can alter ovarian functions after long-term high-fat high-sugar (HFHS) diet feeding. However, the acute impact of obesogenic diets on the follicular cells, and how this impact evolves over...
2.
Meulders B, Marei W, Loier L, Leroy J
Annu Rev Anim Biosci
. 2024 Nov;
13(1):233-254.
PMID: 39565833
Metabolic stress conditions are often characterized by upregulated lipolysis and subsequently increased serum free fatty acid (FFA) concentrations, leading to the uptake of FFAs by non-adipose tissues and impairment of...
3.
Xhonneux I, Marei W, Meulders B, Slootmans J, Pintelon I, Leroy J
PLoS One
. 2024 Jun;
19(6):e0305912.
PMID: 38935642
Diet-induced obesity reduces oocyte quality mainly by impacting oocyte mitochondrial functions. Moreover, maternal obesity is associated with mitochondrial dysfunction in oocytes of their adult offspring. However, these effects were reported...
4.
Xhonneux I, Marei W, Meulders B, Andries S, Leroy J
Front Physiol
. 2024 Apr;
15:1354327.
PMID: 38585221
Consumption of obesogenic (OB) diets increases the prevalence of maternal obesity worldwide, causing major psychological and social burdens in women. Obesity not only impacts the mother's health and fertility but...
5.
Meulders B, Marei W, Xhonneux I, Loier L, Smits A, Leroy J
Int J Mol Sci
. 2024 Feb;
25(4).
PMID: 38396912
Obese individuals often suffer from metabolic health disorders and reduced oocyte quality. Preconception diet interventions in obese outbred mice restore metabolic health and oocyte quality and mitochondrial ultrastructure. Also, studies...
6.
Marei W, Mohey-Elsaeed O, Pintelon I, Leroy J
J Assist Reprod Genet
. 2023 Dec;
41(2):371-383.
PMID: 38146030
Purpose: Oxidative stress and mitochondrial dysfunction play central roles in reduced oocyte quality and infertility in obese patients. Mitochondria-targeted treatments containing co-enzyme Q10 such as mitoquinone (MitoQ) can increase mitochondrial...
7.
Meulders B, Marei W, Xhonneux I, Bols P, Leroy J
Sci Rep
. 2023 Dec;
13(1):21664.
PMID: 38066095
Maternal metabolic disorders may cause lipotoxic effects on the developing oocyte. Understanding the timing at which this might disrupt embryo epigenetic programming and how this is linked with mitochondrial dysfunction...
8.
Meulders B, Leroy J, Xhonneux I, Bols P, Marei W
Reproduction
. 2023 Dec;
167(2).
PMID: 38038651
In Brief: Epigenetic programming is a crucial process during early embryo development that can have a significant impact on the results of assisted reproductive technology (ART) and offspring health. Here...
9.
Xhonneux I, Marei W, Meulders B, Andries S, Leroy J
Front Physiol
. 2023 Nov;
14:1288472.
PMID: 37965107
Obesity affects oocyte mitochondrial functions and reduces oocyte quality and fertility. Obesity may also increase the risk of metabolic disorders in the offspring. Children are likely to follow their parents...
10.
Hedia M, Angel-Velez D, Papas M, Peere S, Gerits I, De Coster T, et al.
Theriogenology
. 2023 Oct;
213:109-113.
PMID: 37826984
The in vitro production of equine embryos via ovum pick-up (OPU) and intracytoplasmic sperm injection (ICSI) has increased rapidly. There is a marked effect of the individual mare on the...