Jiri Forejt
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Explore the profile of Jiri Forejt including associated specialties, affiliations and a list of published articles.
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44
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1865
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Recent Articles
1.
Fotopulosova V, Tanieli G, Fusek K, Jansa P, Forejt J
Mol Biol Evol
. 2024 Oct;
41(10).
PMID: 39404090
Hybrid sterility is a reproductive isolation barrier between diverging taxa securing the early steps of speciation. Hybrid sterility is ubiquitous in the animal and plant kingdoms, but its genetic control...
2.
AbuAlia K, Damm E, Ullrich K, Mukaj A, Parvanov E, Forejt J, et al.
Genetics
. 2024 Jan;
226(3).
PMID: 38217871
PRDM9-mediated reproductive isolation was first described in the progeny of Mus musculus musculus (MUS) PWD/Ph and Mus musculus domesticus (DOM) C57BL/6J inbred strains. These male F1 hybrids fail to complete...
3.
Forejt J, Jansa P
Mol Biol Evol
. 2023 Apr;
40(4).
PMID: 37030001
Hybrid sterility (HS) is an early postzygotic reproductive isolation mechanism observed in all sexually reproducing species. Infertility of hybrids prevents gene flow between incipient species and leads to speciation. While...
4.
Valiskova B, Gregorova S, Lustyk D, Simecek P, Jansa P, Forejt J
Genetics
. 2022 Aug;
222(1).
PMID: 35924978
Hybrid sterility contributes to speciation by preventing gene flow between related taxa. Prdm9, the first and only hybrid male sterility gene known in vertebrates, predetermines the sites of recombination between...
5.
Forejt J, Jansa P, Parvanov E
Trends Genet
. 2021 Jul;
37(12):1095-1108.
PMID: 34238593
Hybrid sterility is a critical step in the evolution of reproductive barriers between diverging taxa during the process of speciation. Recent studies of young subspecies of the house mouse revealed...
6.
Gergelits V, Parvanov E, Simecek P, Forejt J
Genetics
. 2021 Mar;
217(1):1-14.
PMID: 33683354
During meiosis, the recombination-initiating DNA double-strand breaks (DSBs) are repaired by crossovers or noncrossovers (gene conversions). While crossovers are easily detectable, noncrossover identification is hampered by the small size of...
7.
Farrall A, Lienhard M, Grimm C, Kuhl H, Sluka S, Caparros M, et al.
Cancer Res
. 2020 Nov;
81(1):38-49.
PMID: 33154092
Genetic predisposition affects the penetrance of tumor-initiating mutations, such as APC mutations that stabilize β-catenin and cause intestinal tumors in mice and humans. However, the mechanisms involved in genetically predisposed...
8.
Mukaj A, Pialek J, Fotopulosova V, Morgan A, Odenthal-Hesse L, Parvanov E, et al.
Mol Biol Evol
. 2020 Jul;
37(12):3423-3438.
PMID: 32642764
The classical definition posits hybrid sterility as a phenomenon when two parental taxa each of which is fertile produce a hybrid that is sterile. The first hybrid sterility gene in...
9.
Lustyk D, Kinsky S, Ullrich K, Yancoskie M, Kasikova L, Gergelits V, et al.
Genetics
. 2019 Sep;
213(3):1047-1063.
PMID: 31562180
F hybrids between mouse inbred strains PWD and C57BL/6 represent the most thoroughly genetically defined model of hybrid sterility in vertebrates. Hybrid male sterility can be fully reconstituted from three...
10.
Papanikos F, Clement J, Testa E, Ravindranathan R, Grey C, Dereli I, et al.
Mol Cell
. 2019 Apr;
74(5):1069-1085.e11.
PMID: 31000436
Orderly segregation of chromosomes during meiosis requires that crossovers form between homologous chromosomes by recombination. Programmed DNA double-strand breaks (DSBs) initiate meiotic recombination. We identify ANKRD31 as a key component...