Jiqiang Ling
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Explore the profile of Jiqiang Ling including associated specialties, affiliations and a list of published articles.
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64
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1683
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Recent Articles
11.
Augenstreich J, Shuster M, Fan Y, Lyu Z, Ling J, Briken V
bioRxiv
. 2023 Oct;
PMID: 37873092
Accurate quantification of bacterial burden within macrophages, termed Bacterial Burden Quantification (BBQ), is crucial for understanding host-pathogen interactions. Various methods have been employed, each with strengths and weaknesses. This article...
12.
Zhang H, Murphy P, Yu J, Lee S, Tsai F, van Hoof A, et al.
Nucleic Acids Res
. 2023 Sep;
51(19):10606-10618.
PMID: 37742077
Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes that ligate amino acids to tRNAs, and often require editing to ensure accurate protein synthesis. Recessive mutations in aaRSs cause various neurological disorders in...
13.
Lyu Z, Villanueva P, OMalley L, Murphy P, Augenstreich J, Briken V, et al.
Nucleic Acids Res
. 2023 Sep;
51(18):9905-9919.
PMID: 37670559
Translational fidelity is critical for microbial fitness, survival and stress responses. Much remains unknown about the genetic and environmental control of translational fidelity and its single-cell heterogeneity. In this study,...
14.
Lyu Z, Wilson C, Ling J
Pathogens
. 2023 Mar;
12(3).
PMID: 36986305
Translational fidelity refers to accuracy during protein synthesis and is maintained in all three domains of life. Translational errors occur at base levels during normal conditions and may rise due...
15.
Lyu Z, Ling J
Genes (Basel)
. 2022 Feb;
13(2).
PMID: 35205229
Translational fidelity is maintained by multiple quality control steps in all three domains of life. Increased translational errors (mistranslation) occur due to genetic mutations and external stresses. Severe mistranslation is...
16.
Orellana O, Amster-Choder O, Banerjee R, Ling J
Front Microbiol
. 2021 Nov;
12:754109.
PMID: 34777308
No abstract available.
17.
Lyu Z, Yang A, Villanueva P, Singh A, Ling J
mBio
. 2021 Sep;
12(5):e0237421.
PMID: 34579571
Phenotypic heterogeneity among single cells in a genetically identical population leads to diverse environmental adaptation. The human and animal pathogen Salmonella enterica serovar Typhimurium exhibits heterogeneous expression of virulence genes,...
18.
Zhang H, Wu J, Lyu Z, Ling J
Nucleic Acids Res
. 2021 Sep;
49(17):9953-9964.
PMID: 34500470
Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes that provide the ribosome with aminoacyl-tRNA substrates for protein synthesis. Mutations in aaRSs lead to various neurological disorders in humans. Many aaRSs utilize editing...
19.
Zhang H, Lyu Z, Fan Y, Evans C, Barber K, Banerjee K, et al.
Proc Natl Acad Sci U S A
. 2020 Aug;
117(36):22167-22172.
PMID: 32839318
Accurate protein synthesis is a tightly controlled biological process with multiple quality control steps safeguarded by aminoacyl-transfer RNA (tRNA) synthetases and the ribosome. Reduced translational accuracy leads to various physiological...
20.
Yu Q, Mallory J, Kolomeisky A, Ling J, Igoshin O
J Phys Chem Lett
. 2020 May;
11(10):4001-4007.
PMID: 32354218
Living systems maintain a high fidelity in information processing through kinetic proofreading, a mechanism for preferentially removing incorrect substrates at the cost of energy dissipation and slower speed. Proofreading mechanisms...