Jingdan Liang
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Explore the profile of Jingdan Liang including associated specialties, affiliations and a list of published articles.
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38
Citations
544
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Recent Articles
1.
Fang Y, Tan C, Zheng Z, Yang J, Tang J, Guo R, et al.
Biochem Pharmacol
. 2025 Mar;
236:116849.
PMID: 40056941
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignant tumor characterized by a poor prognosis. A prominent feature of PDAC is the rich and dense stroma present in the tumor...
2.
Cao W, Chen S, Wu S, Wang J, Deng Z, Liang J, et al.
Int J Mol Sci
. 2025 Feb;
26(4).
PMID: 40004213
Nonribosomal peptide synthetases (NRPS) are essential for the biosynthesis of therapeutically valuable molecules, including antibiotics, immunosuppressants, and anticancer agents. The assembly-line mechanism of NRPS offers significant potential for engineering novel...
3.
Silli E, Li M, Shao Y, Zhang Y, Hou G, Du J, et al.
Eur J Pharm Biopharm
. 2023 Sep;
192:13-24.
PMID: 37758121
Pancreatic cancer (PC) is an incurable disease with a high death rate in the world nowadays. Gemcitabine (GEM) and Paclitaxel (PTX) are considered as references of chemotherapeutic treatments and are...
4.
Wang J, Deng Z, Liang J, Wang Z
Nat Prod Rep
. 2023 Aug;
40(9):1498-1520.
PMID: 37581222
Time span of literature covered: up to mid-2023Iterative type I polyketide synthases (iPKSs) are outstanding natural chemists: megaenzymes that repeatedly utilize their catalytic domains to synthesize complex natural products with...
5.
Wang J, Wang X, Li X, Kong L, Du Z, Li D, et al.
Nat Commun
. 2023 Mar;
14(1):1319.
PMID: 36899013
Assembly-line polyketide synthases (PKSs) are molecular factories that produce diverse metabolites with wide-ranging biological activities. PKSs usually work by constructing and modifying the polyketide backbone successively. Here, we present the...
6.
Yi D, Wu J, Zhang M, Zeng Q, Wang J, Liang J, et al.
Int J Environ Res Public Health
. 2022 Aug;
19(16).
PMID: 36011462
The debate over whether involution causes anxiety has persisted because no studies have attempted to quantify introversion and study its relationship to anxiety. This study quantified involution and explored its...
7.
Tang S, Li M, Chen L, Dai A, Liu Z, Wu M, et al.
ACS Appl Bio Mater
. 2022 Jun;
5(7):3329-3337.
PMID: 35737819
Thousands of breakthrough infections are confirmed after intramuscular (i.m.) injection of the approved vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Two major factors might contribute to breakthrough infections....
8.
Wang J, Li D, Chen L, Cao W, Kong L, Zhang W, et al.
Nat Commun
. 2022 Feb;
13(1):592.
PMID: 35105906
Nonribosomal peptide synthetases (NRPSs) are modular assembly-line megaenzymes that synthesize diverse metabolites with wide-ranging biological activities. The structural dynamics of synthetic elongation has remained unclear. Here, we present cryo-EM structures...
9.
Wang J, Liang J, Chen L, Zhang W, Kong L, Peng C, et al.
Nat Commun
. 2021 Feb;
12(1):867.
PMID: 33558520
Statins are effective cholesterol-lowering drugs. Lovastatin, one of the precursors of statins, is formed from dihydromonacolin L (DML), which is synthesized by lovastatin nonaketide synthase (LovB), with the assistance of...
10.
Khan H, Liu M, Kayani M, Ahmad S, Liang J, Bai X
Environ Pollut
. 2020 Nov;
268(Pt A):115799.
PMID: 33162214
The mechanism driving the dissemination of antibiotic resistance genes (ARGs) in drinking water supply systems (DWSSs) with multiple barriers remains poorly understood despite several recent efforts. Phosphorothioate (PT) modifications, governed...