Jing Chen-Roetling
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Explore the profile of Jing Chen-Roetling including associated specialties, affiliations and a list of published articles.
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30
Citations
508
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Recent Articles
1.
Yamazaki S, Valekunja U, Chen-Roetling J, Reddy A
bioRxiv
. 2024 Nov;
PMID: 39605613
Heat Shock Factor 1 (HSF1) is a critical transcription factor for cellular proteostasis, but its role in sleep regulation remains unexplored. We demonstrate that nuclear HSF1 levels in the mouse...
2.
Chen-Roetling J, Li Y, Cao Y, Yan Z, Lu X, Regan R
Brain Res
. 2021 Apr;
1765:147507.
PMID: 33930375
Heme release from hemoglobin may contribute to secondary injury after intracerebral hemorrhage (ICH). The primary endogenous defense against heme toxicity is hemopexin, a 57 kDa glycoprotein that is depleted in...
3.
Chen-Roetling J, Cao Y, Peng D, Regan R
Brain Res
. 2019 Jan;
1711:91-96.
PMID: 30639124
The effective time window of any therapeutic in an experimental stroke model is limited by the rate of injury progression. Intracerebral hemorrhage in rodents is commonly induced by striatal injection...
4.
Chen-Roetling J, Regan K, Regan R
Biochem Biophys Res Commun
. 2018 Jun;
503(1):152-156.
PMID: 29859185
Hemorrhage into the brain parenchyma or subarachnoid space is associated with edema and vascular injury that is likely mediated at least in part by the toxicity of hemoglobin. In contrast,...
5.
Chen-Roetling J, Ma S, Cao Y, Shah A, Regan R
J Neurochem
. 2018 Mar;
145(6):464-473.
PMID: 29500821
Hemopexin (Hpx) binds heme with extraordinary affinity, and after haptoglobin may provide a second line of defense against the toxicity of extracellular hemoglobin (Hb). In this series of experiments, the...
6.
Chen-Roetling J, Kamalapathy P, Cao Y, Song W, Schipper H, Regan R
Neurobiol Dis
. 2017 Mar;
102:140-146.
PMID: 28323022
Pharmacotherapies that increase CNS expression of heme oxygenase-1 (HO-1) and other antioxidant proteins have improved outcome in experimental models of spontaneous intracerebral hemorrhage (ICH). In order to more specifically investigate...
7.
Chen-Roetling J, Regan R
Curr Pharm Des
. 2016 Nov;
23(15):2226-2237.
PMID: 27799046
Background: Injury to cells adjacent to an intracerebral hemorrhage (ICH) is likely mediated at least in part by toxins released from the hematoma that initiate complex and interacting injury cascades....
8.
Chen-Roetling J, Regan R
J Neurochem
. 2016 Jul;
139(4):586-595.
PMID: 27364920
Haptoglobin (Hp) binds hemoglobin (Hb) with high affinity and provides the primary defense against its toxicity after intravascular hemolysis. Neurons are exposed to extracellular Hb after CNS hemorrhage, and a...
9.
Chen-Roetling J, Song W, Schipper H, Regan C, Regan R
Stroke
. 2015 Feb;
46(4):1093-8.
PMID: 25690543
Background And Purpose: Heme oxygenase-1 (HO-1) catalyzes the rate-limiting reaction of heme breakdown and may have both antioxidant and pro-oxidant effects. In previous studies, HO-1 overexpression protected astrocytes from heme-mediated...
10.
Chen-Roetling J, Lu X, Regan R
Ther Targets Neurol Dis
. 2015 Feb;
2(1).
PMID: 25642455
Intracerebral hemorrhage (ICH) is the primary event in approximately 10% of strokes, and has higher rates of morbidity and mortality than ischemic stroke. Experimental evidence suggests that the toxicity of...