Jill Giles-Komar
Overview
Explore the profile of Jill Giles-Komar including associated specialties, affiliations and a list of published articles.
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24
Citations
488
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Recent Articles
1.
Santulli-Marotto S, Gervais A, Fisher J, Strake B, Ogden C, Riveley C, et al.
PLoS One
. 2015 Dec;
10(12):e0145078.
PMID: 26674639
Defective clearance of apoptotic cells can result in sustained inflammation and subsequent autoimmunity. Macrophages, the "professional phagocyte" of the body, are responsible for efficient, non-phlogistic, apoptotic cell clearance. Controlling phagocytosis...
2.
Cooper P, Kliwinski C, Perkinson R, Ragwan E, Mabus J, Powers G, et al.
Front Pharmacol
. 2014 Oct;
5:225.
PMID: 25339905
The neonatal Fc receptor (FcRn) in intestinal epithelium is the primary mechanism for transfer of maternal immunoglobulin G (IgG) from suckled milk to serum; but the factors contributing to the...
3.
Hornby P, Cooper P, Kliwinski C, Ragwan E, Mabus J, Harman B, et al.
Pharm Res
. 2013 Sep;
31(4):908-22.
PMID: 24072267
Purpose: To evaluate transcytosis of immunoglobulin G (IgG) by the neonatal Fc receptor (FcRn) in adult primate intestine to determine whether this is a means for oral delivery of monoclonal...
4.
Harman B, Giles-Komar J, Rycyzyn M
Curr Drug Discov Technol
. 2013 Aug;
11(1):65-73.
PMID: 23978038
Since Kohler and Milstein developed the process of generating hybridomas by fusing antibody secreting B cells with an immortal myeloma cell line, the techniques used to develop monoclonal antibodies for...
5.
Yeilding N, Szapary P, Brodmerkel C, Benson J, Plotnick M, Zhou H, et al.
Ann N Y Acad Sci
. 2012 Jul;
1263:1-12.
PMID: 22823582
Since the original publication of the article "Development of the IL-12/23 antagonist ustekinumab in psoriasis: Past, present and future perspectives" in March 2011 (see Appendix),(1) there have been several new...
6.
Spencer S, Bethea D, Shantha Raju T, Giles-Komar J, Feng Y
MAbs
. 2012 Apr;
4(3):319-25.
PMID: 22531448
The successful development of antibody therapeutics depends on the molecules having properties that are suitable for manufacturing, as well as use by patients. Because high solubility is a desirable property...
7.
Ekert J, Murray L, Das A, Sheng H, Giles-Komar J, Rycyzyn M
Fibrogenesis Tissue Repair
. 2011 Oct;
4(1):23.
PMID: 22011363
Background: Fibrocytes are a population of circulating bone-marrow-derived cells that express surface markers for leukocytes and mesenchymal cells, and are capable of differentiating into myofibroblasts. They have been observed at...
8.
Fursov N, Johnston E, Duffy K, Cotty A, Petley T, Fisher J, et al.
Hybridoma (Larchmt)
. 2011 May;
30(2):153-62.
PMID: 21529288
ST2L is a transmembrane receptor that belongs to the IL-1 receptor family. The receptor is expressed on various cell types including Th2 cells, mast cells, basophils, growth-activated fibroblasts, and vascular...
9.
Yeilding N, Szapary P, Brodmerkel C, Benson J, Plotnick M, Zhou H, et al.
Ann N Y Acad Sci
. 2011 Mar;
1222:30-9.
PMID: 21434940
The development of ustekinumab as a first-in-class anti-interleukin (IL) 12/23p40 therapeutic agent for psoriasis represents an important example of modern and rational drug design and development. Psoriasis is a chronic,...
10.
Fursov N, Gates I, Panavas T, Giles-Komar J, Powers G
Assay Drug Dev Technol
. 2011 Feb;
9(4):420-9.
PMID: 21294636
Interleukin-6 (IL-6) family of cytokines are multifunctional proteins that play an important role in host defenses, acute phase reactions, immune responses, hematopoiesis, and tumorigenesis. The cytokines are produced by various...