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Jijia Hu

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Recent Articles
11.
Chen Z, Zhu Z, Liang W, Luo Z, Hu J, Feng J, et al.
Kidney Int . 2023 Feb; 103(4):735-748. PMID: 36731609
Activation of the renin-angiotensin system is associated with podocyte injury and has been well demonstrated as a pivotal factor in the progression of chronic kidney disease. Podocyte energy metabolism is...
12.
Luo Z, Chen Z, Zhu Z, Hao Y, Feng J, Luo Q, et al.
Cell Signal . 2022 Aug; 99:110443. PMID: 35988808
Recent studies have reported that Angiotensin II (Ang II) contributes to podocyte injury by interfering with metabolism. Glycolysis is essential for podocytes and glycolysis abnormality is associated with glomerular injury...
13.
Feng J, Chen Z, Ma Y, Yang X, Zhu Z, Zhang Z, et al.
Int J Biol Sci . 2022 Jul; 18(10):4026-4042. PMID: 35844803
Podocyte injury is involved in the onset and progression of diabetic kidney disease (DKD) and is associated with mitochondrial abnormalities. Defective mitochondrial DNA (mtDNA) replication results in mitochondrial dysfunction. However,...
14.
Chen Z, Liang W, Hu J, Zhu Z, Feng J, Ma Y, et al.
Cell Prolif . 2022 Jul; 55(10):e13296. PMID: 35842903
Objectives: Increasing evidence suggests that mitochondrial dysfunction is the key driver of angiotensin II (Ang II)-induced kidney injury. This study was designed to investigate whether Sirtuin 6 (Sirt6) could affect...
15.
Luo Q, Liang W, Zhang Z, Zhu Z, Chen Z, Hu J, et al.
Metabolism . 2022 Jul; 134:155245. PMID: 35780908
Introduction: Compromised glycolysis in podocytes contributes to the initiation of diabetic kidney disease (DKD). Podocyte injury is characterized by cytoskeletal remodeling and foot process fusion. Compromised glycolysis in diabetes likely...
16.
Hu J, Zhu Z, Chen Z, Yang Q, Liang W, Ding G
Cell Prolif . 2022 May; 55(6):e13229. PMID: 35567428
Objectives: Exposure of podocytes to angiotensin II (Ang II) enhances the abundance of the cell surface glycoprotein, low-density lipoprotein receptor (LDLR) and promotes significant changes in the cellular cholesterol content....
17.
Zhu Z, Hu J, Chen Z, Feng J, Yang X, Liang W, et al.
Metabolism . 2022 Mar; 131:155194. PMID: 35346693
Acute kidney injury (AKI) is a global public health concern associated with high morbidity and mortality. Although advances in medical management have improved the in-hospital mortality of severe AKI patients,...
18.
Zhang Z, Liang W, Luo Q, Hu H, Yang K, Hu J, et al.
Front Endocrinol (Lausanne) . 2022 Jan; 12:797025. PMID: 35095764
Background: Glycolysis dysfunction is an important pathogenesis of podocyte injury in diabetic kidney disease (DKD). Foot process fusion of podocytes and increased albuminuria are markers of early DKD. Moreover, cytoskeletal...
19.
Cao Y, Chen Z, Hu J, Feng J, Zhu Z, Fan Y, et al.
Front Cell Dev Biol . 2022 Jan; 9:769213. PMID: 34988075
The endoplasmic reticulum (ER) stress and mitochondrial dysfunction in high glucose (HG)-induced podocyte injury have been demonstrated to the progression of diabetic kidney disease (DKD). However, the pathological mechanisms remain...
20.
Yang X, Feng J, Liang W, Zhu Z, Chen Z, Hu J, et al.
Cell Mol Life Sci . 2021 Dec; 79(1):53. PMID: 34950960
SIRT6 is an NAD dependent deacetylase that belongs to the mammalian sirtuin family. SIRT6 is mainly located in the nucleus and regulates chromatin remodeling, genome stability, and gene transcription. SIRT6...