Jianqiang Yu
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Explore the profile of Jianqiang Yu including associated specialties, affiliations and a list of published articles.
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Articles
100
Citations
903
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Recent Articles
1.
Qin X, Hou R, Qu Z, Yu J, Zhang W, Ma H, et al.
Bioorg Chem
. 2025 Mar;
158:108350.
PMID: 40073597
The Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway stands as a pivotal mechanism in defending against oxidative stress damage and related inflammation. Blocking the...
2.
Du J, Liu R, Ma L, Liu Y, Wei W, Liu N, et al.
Sci Rep
. 2025 Feb;
15(1):4522.
PMID: 39915556
Histone deacetylase-5 (HDAC5) is implicated in the pathogenesis of depression and the mechanistic pathways underlying the effects of antidepressant medications. We previously identified a novel HDAC5 inhibitor, T2943, with antidepressant...
3.
Wang F, Li K, Wang W, Hui J, He J, Cai J, et al.
Cell Death Dis
. 2024 Oct;
15(10):779.
PMID: 39465258
Excessive DNA damage triggers various types of programmed cell death (PCD), yet the regulatory mechanism of DNA damage-induced cell death is not fully understood. Here, we report that PANoptosis, a...
4.
Lan X, Wang Q, Liu Y, You Q, Wei W, Zhu C, et al.
Redox Biol
. 2024 Oct;
77:103406.
PMID: 39454290
Cerebral ischemia-reperfusion injury (CIRI) refers to a secondary brain injury that occurs when blood supply is restored to ischemic brain tissue and is one of the leading causes of adult...
5.
Zhao Y, Wang Q, Zhu J, Cai J, Feng X, Song Q, et al.
Cell Death Dis
. 2024 Oct;
15(10):764.
PMID: 39433736
Necroptosis and ferroptosis are two distinct forms of necrotic-like cell death in terms of their morphological features and regulatory mechanisms. These two types of cell death can coexist in disease...
6.
Ye Z, Lv Y, Yu J, Zhou K, Jin Y, Liu H
Neurol India
. 2024 Oct;
72(5):1112-1113.
PMID: 39428798
No abstract available.
7.
Liu R, Liu N, Ma L, Liu Y, Huang Z, Peng X, et al.
CNS Drugs
. 2024 Oct;
38(12):985-1002.
PMID: 39379772
Major depressive disorder (MDD) is a severe mental illness with a complex etiology. Currently, many medications employed in clinical treatment exhibit limitations such as delayed onset of action and a...
8.
Wang S, Zhang Y, Yu R, Chai Y, Liu R, Yu J, et al.
J Med Chem
. 2024 Oct;
67(20):17980-17996.
PMID: 39360958
Target identification, employing chemical proteomics, constitutes a continuous challenging endeavor in the drug development of natural products (NPs). Understanding their targets is crucial for deciphering their mechanisms and developing potential...
9.
Wang Y, Lan X, Liu N, Ma L, Du J, Wei W, et al.
Chin J Nat Med
. 2024 Aug;
22(8):746-755.
PMID: 39197964
Ischemic stroke (IS) is a globally prevalent cerebrovascular disorder resulting from cerebral vessel occlusion, leading to significant morbidity and mortality. The intricate pathological mechanisms underlying IS complicate the development of...
10.
Wang J, Zheng P, Yu J, Yang X, Zhang J
RSC Med Chem
. 2024 Jul;
15(7):2212-2225.
PMID: 39026653
Protein-protein interactions are fundamental to nearly all biological processes. Due to their structural flexibility, peptides have emerged as promising candidates for developing inhibitors targeting large and planar PPI interfaces. However,...