Jian-Yuan Li
Overview
Explore the profile of Jian-Yuan Li including associated specialties, affiliations and a list of published articles.
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Articles
37
Citations
406
Followers
0
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Recent Articles
1.
Jimmidi R, Monsivais D, Ta H, Sharma K, Bohren K, Chamakuri S, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(47):e2413108121.
PMID: 39541346
Activin receptor type 1 (ACVR1; ALK2) and activin receptor like type 1 (ACVRL1; ALK1) are transforming growth factor beta family receptors that integrate extracellular signals of bone morphogenic proteins (BMPs)...
2.
Ku A, Sharma K, Ta H, Sutton C, Bohren K, Wang Y, et al.
Science
. 2024 May;
384(6698):885-890.
PMID: 38781365
Men or mice with homozygous serine/threonine kinase 33 () mutations are sterile owing to defective sperm morphology and motility. To chemically evaluate STK33 for male contraception with STK33-specific inhibitors, we...
3.
Shi H, Li Q, Li H, Wang H, Fan C, Dong Q, et al.
Hum Reprod
. 2023 Nov;
39(2):310-325.
PMID: 38011909
Study Question: What is the mechanism behind cryoinjury in human sperm, particularly concerning the interplay between reactive oxygen species (ROS) and autophagy, and how does it subsequently affect sperm fate?...
4.
Jimmidi R, Chamakuri S, Lu S, Ucisik M, Chen P, Bohren K, et al.
Commun Chem
. 2023 Aug;
6(1):164.
PMID: 37542196
The development of SARS-CoV-2 main protease (M) inhibitors for the treatment of COVID-19 has mostly benefitted from X-ray structures and preexisting knowledge of inhibitors; however, an efficient method to generate...
5.
Modukuri R, Monsivais D, Li F, Palaniappan M, Bohren K, Tan Z, et al.
J Med Chem
. 2023 Jan;
66(3):2143-2160.
PMID: 36719862
The discovery of monokinase-selective inhibitors for patients is challenging because the 500+ kinases encoded by the human genome share highly conserved catalytic domains. Until now, no selective inhibitors unique for...
6.
Ye Q, Belabed H, Wang Y, Yu Z, Palaniappan M, Li J, et al.
Andrology
. 2022 Oct;
11(5):808-815.
PMID: 36209044
Background: A safe, effective, and reversible nonhormonal male contraceptive drug is greatly needed for male contraception as well as for circumventing the side effects of female hormonal contraceptives. Phosducin-like 2...
7.
Lin H, Xiao P, Bu R, Guo S, Yang Z, Yuan D, et al.
Nat Chem Biol
. 2022 Aug;
18(11):1196-1203.
PMID: 35982227
Adhesion G protein-coupled receptors are elusive in terms of their structural information and ligands. Here, we solved the cryogenic-electron microscopy (cryo-EM) structure of apo-ADGRG2, an essential membrane receptor for maintaining...
8.
Chamakuri S, Lu S, Ucisik M, Bohren K, Chen Y, Du H, et al.
Proc Natl Acad Sci U S A
. 2021 Aug;
118(36).
PMID: 34426525
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed more than 4 million humans globally, but there is no bona fide Food and Drug Administration-approved drug-like molecule to impede the...
9.
Boylan A, Nguyen T, Lundy B, Li J, Vallakati R, Sundstrom S, et al.
Molecules
. 2021 Apr;
26(6).
PMID: 33799473
Two key factors bear on reaction rates for the conjugate addition of alkenyl boronic acids to heteroaryl-appended enones: the proximity of inductively electron-withdrawing heteroatoms to the site of bond formation...
10.
Liao Z, Li J, Mo X, Ni Z, Jiang W, He Y, et al.
Res Microbiol
. 2019 Nov;
171(2):102-106.
PMID: 31669369
Xanthomonas oryzae pv. oryzicola (Xoc) depends on its type III secretion system (T3SS) to translocate type III secreted effectors (T3SEs), including transcription activator-like effectors (TALEs) and non-transcription activator-like effectors (non-TALEs),...