Jian-Jun Wen
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Explore the profile of Jian-Jun Wen including associated specialties, affiliations and a list of published articles.
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25
Citations
733
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Recent Articles
1.
Sonowal H, Pal P, Wen J, Awasthi S, Ramana K, Srivastava S
Sci Rep
. 2017 Jun;
7(1):3182.
PMID: 28600556
Anthracycline drugs such as doxorubicin (DOX) and daunorubicin remain some of the most active wide-spectrum and cost-effective drugs in cancer therapy. However, colorectal cancer (CRC) cells are inherently resistant to...
2.
Wan X, Wen J, Koo S, Liang L, Garg N
PLoS Pathog
. 2016 Oct;
12(10):e1005954.
PMID: 27764247
Chronic chagasic cardiomyopathy (CCM) is presented by increased oxidative/inflammatory stress and decreased mitochondrial bioenergetics. SIRT1 senses the redox changes and integrates mitochondrial metabolism and inflammation; and SIRT1 deficiency may be...
3.
Wen J, Wan X, Thacker J, Garg N
JACC Basic Transl Sci
. 2016 Oct;
1(4):235-250.
PMID: 27747306
Background: Chagasic cardiomyopathy (CCM) caused by () infection is prevalent in Latin America and recognized as an emerging infectious heart disease in the US. The NO-cGMP-PKG1α pathway maintains cardiac homeostasis...
4.
Wen J, Nagajyothi F, Machado F, Weiss L, Scherer P, Tanowitz H, et al.
Parasitol Res
. 2014 Jun;
113(9):3159-65.
PMID: 24948102
The protozoan parasite Trypanosoma cruzi causes Chagas disease. Cardiac and adipose tissues are among the early targets of infection and are sites of persistent infection. In the heart and adipose...
5.
Wen J, Zago M, Nunez S, Gupta S, Burgos F, Garg N
Mol Cell Proteomics
. 2012 May;
11(8):435-52.
PMID: 22543060
Chagas disease is initiated upon infection by Trypanosoma cruzi. Among the health consequences is a decline in heart function, and the pathophysiological mechanisms underlying this manifestation are not well understood....
6.
Wen J, Garg N
Mol Cell Proteomics
. 2011 Dec;
11(4):M111.010918.
PMID: 22199233
Inflammation and oxidative stress, elicited by Trypanosoma cruzi infection, are important pathologic events during progressive Chagasic cardiomyopathy. In this study, we infected Sprague-Dawley rats with T. cruzi, and treated with...
7.
Gupta S, Dhiman M, Wen J, Garg N
Adv Parasitol
. 2011 Sep;
76:153-70.
PMID: 21884891
Inflammation is a host defence activated by exogenous (e.g. pathogen-derived, pollutants) or endogenous (e.g. reactive oxygen species-ROS) danger signals. Mostly, endogenous molecules (or their derivatives) have well-defined intracellular function but...
8.
Liu M, Wen J, Xu X, Zhao D
Neurochem Res
. 2011 May;
36(10):1863-9.
PMID: 21607610
Prion diseases are conformational diseases, many factors are involved in altering the conformation of prion, such as RNA, DNA, pH, and copper etc. However the neurotoxic mechanism of prion diseases...
9.
Wen J, Gupta S, Guan Z, Dhiman M, Condon D, Lui C, et al.
J Am Coll Cardiol
. 2010 Jun;
55(22):2499-508.
PMID: 20510218
Objectives: The purpose of this study was to determine the pathological importance of oxidative stress-induced injurious processes in chagasic heart dysfunction. Background: Trypanosoma cruzi-induced inflammatory pathology and a feedback cycle...
10.
Gupta S, Bhatia V, Wen J, Wu Y, Huang M, Garg N
Free Radic Biol Med
. 2009 Aug;
47(10):1414-21.
PMID: 19686837
In this study, we investigated the role of Trypanosoma cruzi invasion and inflammatory processes in reactive oxygen species (ROS) production in a mouse atrial cardiomyocyte line (HL-1) and primary adult...