Jia Newcombe
Overview
Explore the profile of Jia Newcombe including associated specialties, affiliations and a list of published articles.
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55
Citations
3140
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Recent Articles
1.
Colombo E, Bacigaluppi M, Bartoccetti M, Triolo D, Bassani C, Bergamaschi A, et al.
Neurobiol Dis
. 2024 Sep;
201:106670.
PMID: 39303814
Following ischemic stroke astrocytes undergo rapid molecular and functional changes that may accentuate tissue damage. In this study we identified the neurotrophin receptor TrkB in astrocytes as a key promoter...
2.
Pujol M, Paskevicius T, Robinson A, Dhillon S, Eggleton P, Ferecsko A, et al.
Int J Mol Sci
. 2024 Sep;
25(17).
PMID: 39273210
The infiltration of immune cells into the central nervous system mediates the development of autoimmune neuroinflammatory diseases. We previously showed that the loss of either Fabp5 or calnexin causes resistance...
3.
Brown A, Wilkins O, Keuss M, Hill S, Zanovello M, Lee W, et al.
Nature
. 2024 Jun;
631(8020):E7.
PMID: 38890465
No abstract available.
4.
Ferecsko A, Smallwood M, Moore A, Liddle C, Newcombe J, Holley J, et al.
Biomedicines
. 2023 May;
11(5).
PMID: 37239045
Background: Some neurodegenerative diseases have an element of neuroinflammation that is triggered by viral nucleic acids, resulting in the generation of type I interferons. In the cGAS-STING pathway, microbial and...
5.
Brown A, Wilkins O, Keuss M, Hill S, Zanovello M, Lee W, et al.
Nature
. 2022 Feb;
603(7899):131-137.
PMID: 35197628
Variants of UNC13A, a critical gene for synapse function, increase the risk of amyotrophic lateral sclerosis and frontotemporal dementia, two related neurodegenerative diseases defined by mislocalization of the RNA-binding protein...
6.
Hasan R, Humphrey J, Bettencourt C, Newcombe J, Lashley T, Fratta P, et al.
Acta Neuropathol
. 2021 Dec;
143(3):383-401.
PMID: 34961893
Frontotemporal lobar degeneration (FTLD) is a group of heterogeneous neurodegenerative disorders affecting the frontal and temporal lobes of the brain. Nuclear loss and cytoplasmic aggregation of the RNA-binding protein TDP-43...
7.
Rivellini C, Porrello E, Dina G, Mrakic-Sposta S, Vezzoli A, Bacigaluppi M, et al.
J Clin Invest
. 2021 Dec;
132(3).
PMID: 34874913
Oligodendrocytes are the primary target of demyelinating disorders, and progressive neurodegenerative changes may evolve in the CNS. DNA damage and oxidative stress are considered key pathogenic events, but the underlying...
8.
Colombo E, Triolo D, Bassani C, Bedogni F, Di Dario M, Dina G, et al.
Proc Natl Acad Sci U S A
. 2021 Jun;
118(27).
PMID: 34183414
Demyelination is a key pathogenic feature of multiple sclerosis (MS). Here, we evaluated the astrocyte contribution to myelin loss and focused on the neurotrophin receptor TrkB, whose up-regulation on the...
9.
Hagemann C, Tyzack G, Taha D, Devine H, Greensmith L, Newcombe J, et al.
Brain Pathol
. 2021 Feb;
31(4):e12937.
PMID: 33576079
Histopathological analysis of tissue sections is invaluable in neurodegeneration research. However, cell-to-cell variation in both the presence and severity of a given phenotype is a key limitation of this approach,...
10.
Paskevicius T, Jung J, Pujol M, Eggleton P, Qin W, Robinson A, et al.
FASEB J
. 2020 Oct;
34(12):16662-16675.
PMID: 33124722
We previously showed that calnexin (Canx)-deficient mice are desensitized to experimental autoimmune encephalomyelitis (EAE) induction, a model that is frequently used to study inflammatory demyelinating diseases, due to increased resistance...