Jerold Jeyaratnam
Overview
Explore the profile of Jerold Jeyaratnam including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
252
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0
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Recent Articles
1.
Mevalonate kinase deficiency: an updated clinical overview and revision of the SHARE recommendations
Lengvari L, Takacs K, Lengyel A, Palinkas A, Wouters C, Kone-Paut I, et al.
Front Immunol
. 2024 Nov;
15:1466844.
PMID: 39600705
Mevalonate kinase deficiency (MKD), a rare auto-inflammatory disorder, arises from mutations in the gene, disrupting isoprenoid biosynthesis, and affecting cellular processes. This comprehensive review provides an updated perspective on MKD,...
2.
Jeyaratnam J, Faraci M, Gennery A, Drabko K, Algeri M, Morimoto A, et al.
Pediatr Rheumatol Online J
. 2022 Jul;
20(1):56.
PMID: 35906690
Objectives: Mevalonate kinase deficiency (MKD) is a rare autoinflammatory syndrome. Several reports have described allogeneic hematopoietic stem cell transplantation in severely affected patients, sometimes with promising results. In view of...
3.
Jeyaratnam J, Simon A, Calvo I, Constantin T, Shcherbina A, Hofer M, et al.
Rheumatology (Oxford)
. 2021 Sep;
61(5):2088-2094.
PMID: 34554243
Objectives: To evaluate the long-term efficacy and safety of canakinumab in patients with mevalonate kinase deficiency during the open label extension (weeks 41-113) of the randomized controlled CLUSTER trial. Methods:...
4.
Jeyaratnam J, Frenkel J
Front Immunol
. 2020 Jun;
11:1150.
PMID: 32582214
Mevalonate kinase deficiency (MKD) is an inborn error of metabolism leading to a syndrome characterized by recurrent inflammation. This clinically manifests itself as fever and can be accompanied by gastrointestinal...
5.
Van Gorp H, Huang L, Saavedra P, Vuylsteke M, Asaoka T, Prencipe G, et al.
Ann Rheum Dis
. 2020 Apr;
79(7):960-968.
PMID: 32312770
Background And Objective: Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease (AID) worldwide. The disease is caused by mutations in the gene encoding the inflammasome sensor Pyrin....
6.
Jeyaratnam J, Ter Haar N, Lachmann H, Kasapcopur O, Ombrello A, Rigante D, et al.
Pediatr Rheumatol Online J
. 2018 Mar;
16(1):19.
PMID: 29562920
Background: Withholding live-attenuated vaccines in patients using interleukin (IL)-1 or IL-6 blocking agents is recommended by guidelines for both pediatric and adult rheumatic diseases, since there is a risk of...
7.
Ter Haar N, Jeyaratnam J, Lachmann H, Simon A, Brogan P, Doglio M, et al.
Arthritis Rheumatol
. 2016 May;
68(11):2795-2805.
PMID: 27213830
Objective: Mevalonate kinase deficiency (MKD) is a rare metabolic disease characterized by recurrent inflammatory episodes. This study was undertaken to describe the genotype, phenotype, and response to treatment in an...
8.
Jeyaratnam J, Ter Haar N, de Sain-van der Velden M, Waterham H, van Gijn M, Frenkel J
JIMD Rep
. 2015 Sep;
27:33-8.
PMID: 26409462
Objective: In patients suffering from mevalonate kinase deficiency (MKD), the reduced enzyme activity leads to an accumulation of mevalonic acid which is excreted in the urine. This study aims to...
9.
Ter Haar N, Oswald M, Jeyaratnam J, Anton J, Barron K, Brogan P, et al.
Ann Rheum Dis
. 2015 Jun;
74(9):1636-44.
PMID: 26109736
: Autoinflammatory diseases are characterised by fever and systemic inflammation, with potentially serious complications. Owing to the rarity of these diseases, evidence-based guidelines are lacking. In 2012, the European project...