Jeroen V Koomen
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Explore the profile of Jeroen V Koomen including associated specialties, affiliations and a list of published articles.
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21
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65
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Recent Articles
1.
Vellinga R, Koomen J, Eleveld D, Stohr T, Pesic M, Struys M, et al.
Anesthesiology
. 2025 Mar;
142(4):666-679.
PMID: 40067039
Background: Synergistic effects between opioids and remimazolam on Bispectral Index (BIS) and Modified Observer's Assessment of Alertness and Sedation (MOAAS) score were previously described. This study aimed to characterize the...
2.
Simons C, Maton L, van Dartel M, van den Heuvel M, den Otter L, Versantvoort C, et al.
Br J Clin Pharmacol
. 2025 Jan;
PMID: 39844429
Aims: For new medicines, drug companies obtain regulatory approval on the strategy to generate evidence in the paediatric population, which can be supported by extrapolation of evidence obtained in a...
3.
Kong D, Roberts J, Lipman J, Taccone F, Cohen-Wolkowiez M, Sime F, et al.
Clin Pharmacokinet
. 2024 Dec;
64(1):107-126.
PMID: 39722108
Background And Objectives: The pharmacokinetics (PK) of piperacillin/tazobactam (PIP/TAZ) is highly variable across different patient populations and there are controversies regarding non-linear elimination as well as the fraction unbound of...
4.
Li Y, Koomen J, Eleveld D, van den Berg J, Vos J, de Keijzer I, et al.
Clin Pharmacokinet
. 2024 Oct;
63(11):1597-1608.
PMID: 39465453
Background: Intraoperation hypotension (IOH) is commonly observed in patients undergoing surgery under general anesthesia, and even a brief episode of IOH can lead to unfavorable outcomes. To reduce the risk,...
5.
Heikal O, van Rheenen P, Touw D, Kosterink J, Maurer M, Koomen J, et al.
Br J Clin Pharmacol
. 2024 Jun;
90(9):2200-2214.
PMID: 38845210
Aims: Use of infliximab (IFX) has improved outcomes in children with inflammatory bowel disease (IBD). However, a proportion of patients does not respond to IFX or loses response over time....
6.
Vellinga R, Koomen J, Eleveld D, Stohr T, Pesic M, Struys M, et al.
Anesthesiology
. 2023 Oct;
140(2):207-219.
PMID: 37889844
Background: Remimazolam exhibits sedative properties by binding to γ-aminobutyric acid type A receptors. Remimazolam is administered as a bolus dose or continuous infusion, but has not been studied using target-controlled...
7.
Kroneisl M, Spraakman N, Koomen J, Hijazi Z, Hoogstra-Berends F, Leuvenink H, et al.
Int J Mol Sci
. 2023 Sep;
24(17).
PMID: 37686384
During ischemia and reperfusion injury (IRI), mitochondria may release mitochondrial DNA (mtDNA). mtDNA can serve as a propagator of further injury but in specific settings has anti-inflammatory capacities as well....
8.
Su H, Koomen J, Eleveld D, Struys M, Colin P
Br J Anaesth
. 2023 Jun;
131(2):222-233.
PMID: 37355412
Background: Propofol and remifentanil are frequently combined for the induction and maintenance of general anaesthesia. Both propofol and remifentanil cause vasodilation and potentially reduce arterial BP. We aimed to develop...
9.
Koomen J, Knobbe T, Zijp T, Kremer D, Gan C, Verschuuren E, et al.
Clin Pharmacokinet
. 2023 Jun;
62(8):1117-1128.
PMID: 37306899
Background And Objective: Historically, dosing of tacrolimus is guided by therapeutic drug monitoring (TDM) of the whole blood concentration, which is strongly influenced by haematocrit. The therapeutic and adverse effects...
10.
van der Hoek S, Koomen J, van Bommel E, Mosterd C, Scholtes R, Hesp A, et al.
J Pers Med
. 2023 May;
13(5).
PMID: 37240917
Sodium-glucose cotransporter-2 (SGLT2) inhibitors improve markers for renal and cardiovascular outcomes in patients with and without type 2 diabetes (T2D). To assess whether individual differences in plasma drug exposure can...