Jeroen Overman
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Explore the profile of Jeroen Overman including associated specialties, affiliations and a list of published articles.
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10
Citations
170
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Recent Articles
1.
Andreasson M, Donzel M, Abrahamsson A, Berner A, Doimo M, Quiroga A, et al.
J Med Chem
. 2024 Jan;
67(3):2202-2219.
PMID: 38241609
G-Quadruplex (G4) DNA structures are important regulatory elements in central biological processes. Small molecules that selectively bind and stabilize G4 structures have therapeutic potential, and there are currently >1000 known...
2.
Correction: Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice
Overman J, Fontaine F, Moustaqil M, Mittal D, Sierecki E, Sacilotto N, et al.
Elife
. 2023 Aug;
12.
PMID: 37551662
No abstract available.
3.
Overman J, Fontaine F, Wylie-Sears J, Moustaqil M, Huang L, Meurer M, et al.
Elife
. 2019 Jul;
8.
PMID: 31358114
Propranolol is an approved non-selective β-adrenergic blocker that is first line therapy for infantile hemangioma. Despite the clinical benefit of propranolol therapy in hemangioma, the mechanistic understanding of what drives...
4.
Moustaqil M, Fontaine F, Overman J, McCann A, Bailey T, Rudolffi Soto P, et al.
Nucleic Acids Res
. 2018 Oct;
46(21):11381-11395.
PMID: 30335167
During embryogenesis, vascular development relies on a handful of transcription factors that instruct cell fate in a distinct sub-population of the endothelium (1). The SOXF proteins that comprise SOX7, 17...
5.
Chiang I, Fritzsche M, Pichol-Thievend C, Neal A, Holmes K, Lagendijk A, et al.
Development
. 2017 Oct;
144(20):3847-3848.
PMID: 29042478
No abstract available.
6.
Chiang I, Fritzsche M, Pichol-Thievend C, Neal A, Holmes K, Lagendijk A, et al.
Development
. 2017 Jun;
144(14):2629-2639.
PMID: 28619820
Arterial specification and differentiation are influenced by a number of regulatory pathways. While it is known that the Vegfa-Notch cascade plays a central role, the transcriptional hierarchy controlling arterial specification...
7.
Fontaine F, Overman J, Moustaqil M, Mamidyala S, Salim A, Narasimhan K, et al.
Cell Chem Biol
. 2017 Feb;
24(3):346-359.
PMID: 28163017
Pharmacological modulation of transcription factors (TFs) has only met little success over the past four decades. This is mostly due to standard drug discovery approaches centered on blocking protein/DNA binding...
8.
Overman J, Fontaine F, Moustaqil M, Mittal D, Sierecki E, Sacilotto N, et al.
Elife
. 2017 Feb;
6.
PMID: 28137359
Pharmacological targeting of transcription factors holds great promise for the development of new therapeutics, but strategies based on blockade of DNA binding, nuclear shuttling, or individual protein partner recruitment have...
9.
Fontaine F, Overman J, Francois M
Cell Regen
. 2015 Apr;
4(1):2.
PMID: 25848531
Much research on transcription factor biology and their genetic pathways has been undertaken over the last 30 years, especially in the field of developmental biology and cancer. Yet, very little...
10.
Vilums M, Overman J, Klaasse E, Scheel O, Brussee J, IJzerman A
ChemMedChem
. 2011 Sep;
7(1):107-13.
PMID: 21919210
Cardiotoxicity is a common side effect of a large variety of drugs that is often caused by off-target human ether-à-go-go-related gene (hERG) potassium channel blockade. In this study, we designed...