Jeremy B Swann
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Explore the profile of Jeremy B Swann including associated specialties, affiliations and a list of published articles.
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29
Citations
2427
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Recent Articles
11.
Hirakawa M, Nagakubo D, Kanzler B, Avilov S, Krauth B, Happe C, et al.
Sci Rep
. 2018 Jul;
8(1):11095.
PMID: 30038304
The numbers of thymic epithelial cells (TECs) and thymocytes steadily increase during embryogenesis. To examine this dynamic, we generated several TEC-specific transgenic mouse lines, which express fluorescent proteins in the...
12.
Nagakubo D, Swann J, Birmelin S, Boehm T
Int Immunol
. 2017 Oct;
29(8):385-390.
PMID: 28992076
Autoimmune and inflammatory conditions are frequent complications in patients with reduced numbers of T cells. Here, we describe a mouse model of thymic stromal dysplasia resulting in peripheral T-cell lymphopenia....
13.
Swann J, Krauth B, Happe C, Boehm T
Sci Rep
. 2017 Aug;
7(1):8492.
PMID: 28819138
Thymopoiesis strictly depends on the function of the Foxn1 transcription factor that is expressed in the thymic epithelium. During embryonic development, initial expression of the Foxn1 gene is induced in...
14.
Swann J, Happe C, Boehm T
Sci Rep
. 2017 Apr;
7(1):785.
PMID: 28400578
All vertebrates possess a thymus, whose epithelial microenvironment is essential for T cell development and maturation. Despite the importance of the thymus for cellular immune defense, many questions surrounding its...
15.
Boehm T, Swann J
Annu Rev Anim Biosci
. 2014 Nov;
2:259-83.
PMID: 25384143
The evolutionary emergence of vertebrates was accompanied by major morphological and functional innovations, including the development of an adaptive immune system. Vertebrate adaptive immunity is based on the clonal expression...
16.
Swann J, Weyn A, Nagakubo D, Bleul C, Toyoda A, Happe C, et al.
Cell Rep
. 2014 Aug;
8(4):1184-97.
PMID: 25131198
The thymus is a lymphoid organ unique to vertebrates, and it provides a unique microenvironment that facilitates the differentiation of immature hematopoietic precursors into mature T cells. We subjected the...
17.
Venkatesh B, Lee A, Swann J, Ohta Y, Flajnik M, Kasahara M, et al.
Nature
. 2014 Jul;
511(7508):E9-10.
PMID: 25008535
No abstract available.
18.
Venkatesh B, Lee A, Ravi V, Maurya A, Lian M, Swann J, et al.
Nature
. 2014 Jan;
505(7482):174-9.
PMID: 24402279
The emergence of jawed vertebrates (gnathostomes) from jawless vertebrates was accompanied by major morphological and physiological innovations, such as hinged jaws, paired fins and immunoglobulin-based adaptive immunity. Gnathostomes subsequently diverged...
19.
Boehm T, Swann J
Nat Rev Immunol
. 2013 Sep;
13(11):831-8.
PMID: 24052146
In vertebrates, the thymus is the main site of T cell development. The thymus reaches its maximum output during adolescence, after which it shrinks and generates fewer and fewer T...
20.
Boehm T, Hess I, Swann J
Trends Immunol
. 2012 Apr;
33(6):315-21.
PMID: 22483556
Lymphoid organs are integral parts of all vertebrate adaptive immune systems. Primary lymphoid tissues exhibit a remarkable functional dichotomy: T cells develop in specialized thymopoietic tissues located in the pharynx,...