Jenhan Tao
Overview
Explore the profile of Jenhan Tao including associated specialties, affiliations and a list of published articles.
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12
Citations
599
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Recent Articles
1.
Shen Z, Li R, Prohaska T, Hoeksema M, Spann N, Tao J, et al.
Elife
. 2022 Jan;
11.
PMID: 35049498
Regulation of gene expression requires the combinatorial binding of sequence-specific transcription factors (TFs) at promoters and enhancers. Prior studies showed that alterations in the spacing between TF binding sites can...
2.
Shamie I, Duttke S, Karottki K, Han C, Hansen A, Hefzi H, et al.
NAR Genom Bioinform
. 2021 Jul;
3(3):lqab061.
PMID: 34268494
Chinese hamster ovary (CHO) cells are widely used for producing biopharmaceuticals, and engineering gene expression in CHO is key to improving drug quality and affordability. However, engineering gene expression or...
3.
Schlachetzki J, Prots I, Tao J, Chun H, Saijo K, Gosselin D, et al.
Sci Rep
. 2020 Apr;
10(1):6261.
PMID: 32253373
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
4.
Fonseca G, Tao J, Westin E, Duttke S, Spann N, Strid T, et al.
Nat Commun
. 2019 Jan;
10(1):414.
PMID: 30679424
Mechanisms by which members of the AP-1 family of transcription factors play non-redundant biological roles despite recognizing the same DNA sequence remain poorly understood. To address this question, here we...
5.
Shemer A, Grozovski J, Tay T, Tao J, Volaski A, Suss P, et al.
Nat Commun
. 2018 Dec;
9(1):5206.
PMID: 30523248
Microglia are yolk sac-derived macrophages residing in the parenchyma of brain and spinal cord, where they interact with neurons and other glial. After different conditioning paradigms and bone marrow (BM)...
6.
Schlachetzki J, Prots I, Tao J, Chun H, Saijo K, Gosselin D, et al.
Sci Rep
. 2018 Jul;
8(1):10757.
PMID: 30018301
Microglia are the main immune cells of the brain and express a large genetic pattern of genes linked to Parkinson's disease risk alleles. Monocytes like microglia are myeloid-lineage cells, raising...
7.
Link V, Duttke S, Chun H, Holtman I, Westin E, Hoeksema M, et al.
Cell
. 2018 May;
173(7):1796-1809.e17.
PMID: 29779944
Non-coding genetic variation is a major driver of phenotypic diversity and allows the investigation of mechanisms that control gene expression. Here, we systematically investigated the effects of >50 million variations...
8.
Muse E, Yu S, Edillor C, Tao J, Spann N, Troutman T, et al.
Proc Natl Acad Sci U S A
. 2018 Apr;
115(20):E4680-E4689.
PMID: 29632203
Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol transport and protects against atherosclerosis in mouse models. Most synthetic LXR agonists also cause marked hypertriglyceridemia by inducing...
9.
Oishi Y, Spann N, Link V, Muse E, Strid T, Edillor C, et al.
Cell Metab
. 2017 Jan;
25(2):412-427.
PMID: 28041958
Macrophages play pivotal roles in both the induction and resolution phases of inflammatory processes. Macrophages have been shown to synthesize anti-inflammatory fatty acids in an LXR-dependent manner, but whether the...
10.
Eichenfield D, Troutman T, Link V, Lam M, Cho H, Gosselin D, et al.
Elife
. 2016 Jul;
5.
PMID: 27462873
Although macrophages can be polarized to distinct phenotypes in vitro with individual ligands, in vivo they encounter multiple signals that control their varied functions in homeostasis, immunity, and disease. Here,...