Jelle van Schooten
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Explore the profile of Jelle van Schooten including associated specialties, affiliations and a list of published articles.
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17
Citations
1202
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Recent Articles
1.
Nelson A, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, et al.
Sci Immunol
. 2024 Aug;
9(98):eadm7097.
PMID: 39213340
Adolescents are a growing population of people living with HIV. The period between weaning and sexual debut presents a low-risk window for HIV acquisition, making early childhood an ideal time...
2.
Caniels T, Medina-Ramirez M, Zhang S, Kratochvil S, Xian Y, Koo J, et al.
Sci Immunol
. 2024 Aug;
9(98):eadk9550.
PMID: 39213338
Eliciting potent and broadly neutralizing antibodies (bnAbs) is a major goal in HIV-1 vaccine development. Here, we describe how germline-targeting immunogen BG505 SOSIP germline trimer 1.1 (GT1.1), generated through structure-based...
3.
Duan H, Corrigan A, Cheng C, Biju A, Gonelli C, Olia A, et al.
iScience
. 2024 Feb;
27(2):108877.
PMID: 38318357
Soluble 'SOSIP'-stabilized HIV-1 envelope glycoprotein (Env) trimers elicit dominant antibody responses targeting their glycan-free base regions, potentially diminishing neutralizing responses. Previously, using a nonhuman primate model, we demonstrated that priming...
4.
Nelson A, Shen X, Vekatayogi S, Zhang S, Ozorowski G, Dennis M, et al.
bioRxiv
. 2023 Nov;
PMID: 37986885
A vaccine that can achieve protective immunity prior to sexual debut is critical to prevent the estimated 410,000 new HIV infections that occur yearly in adolescents. As children living with...
5.
Gristick H, Hartweger H, Loewe M, van Schooten J, Ramos V, Oliveira T, et al.
Sci Immunol
. 2023 Feb;
8(80):eade6364.
PMID: 36763635
Passive transfer of broadly neutralizing anti-HIV-1 antibodies (bNAbs) protects against infection, and therefore, eliciting bNAbs by vaccination is a major goal of HIV-1 vaccine efforts. bNAbs that target the CD4...
6.
van Schooten J, Schorcht A, Farokhi E, Umotoy J, Gao H, van den Kerkhof T, et al.
PLoS Pathog
. 2022 Nov;
18(11):e1010945.
PMID: 36395347
Broadly neutralizing antibodies (bNAbs) have remarkable breadth and potency against most HIV-1 subtypes and are able to prevent HIV-1 infection in animal models. However, bNAbs are extremely difficult to induce...
7.
van Schooten J, Farokhi E, Schorcht A, van den Kerkhof T, Gao H, van der Woude P, et al.
Nat Commun
. 2022 Aug;
13(1):4515.
PMID: 35922441
A major goal of current HIV-1 vaccine design efforts is to induce broadly neutralizing antibodies (bNAbs). The VH1-2-derived bNAb IOMA directed to the CD4-binding site of the HIV-1 envelope glycoprotein...
8.
Maisonnasse P, Aldon Y, Marc A, Marlin R, Dereuddre-Bosquet N, Kuzmina N, et al.
Nat Commun
. 2021 Oct;
12(1):6097.
PMID: 34671037
Effective treatments against Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) are urgently needed. Monoclonal antibodies have shown promising results in patients. Here, we evaluate the in vivo prophylactic and therapeutic...
9.
Schorcht A, Cottrell C, Pugach P, Ringe R, Han A, Allen J, et al.
J Virol
. 2021 Oct;
96(1):e0155221.
PMID: 34669426
The human immunodeficiency virus type 1 (HIV-1) trimeric envelope glycoprotein (Env) is heavily glycosylated, creating a dense glycan shield that protects the underlying peptidic surface from antibody recognition. The absence...
10.
van Schooten J, van Haaren M, Li H, McCoy L, Havenar-Daughton C, Cottrell C, et al.
PLoS Pathog
. 2021 Aug;
17(8):e1009736.
PMID: 34432859
The development of an effective human immunodeficiency virus (HIV-1) vaccine is a high global health priority. Soluble native-like HIV-1 envelope glycoprotein trimers (Env), including those based on the SOSIP design,...