Jeffrey T Irelan
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Explore the profile of Jeffrey T Irelan including associated specialties, affiliations and a list of published articles.
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5
Citations
701
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Recent Articles
1.
Guan N, Deng J, Li T, Xu X, Irelan J, Wang M
Mol Biosyst
. 2013 Mar;
9(5):1035-43.
PMID: 23483079
T cells play a critical role in maintaining the normal function of the adaptive immune response, with their dysfunction resulting in a variety of autoimmune and immunodeficiency diseases. Efficient and...
2.
Irelan J, Wu M, Morgan J, Ke N, Xi B, Wang X, et al.
J Biomol Screen
. 2011 Feb;
16(3):313-22.
PMID: 21310850
Strict quality control of cells is required for the standardization and interpretation of results in all areas of cell-based research, especially in drug discovery. Real-time cellular analysis using electrical impedance...
3.
Irelan J, Gutierrez Del Arroyo A, Gutierrez A, Peters G, Quon K, Miraglia L, et al.
PLoS One
. 2009 Apr;
4(4):e5067.
PMID: 19340300
The CDKN2A locus encodes two important tumor suppressors, INK4a and ARF, which respond to oncogenic stresses by inducing cellular senescence. We conducted a genome-scale cDNA overexpression screen using a reporter...
4.
Konig R, Zhou Y, Elleder D, Diamond T, Bonamy G, Irelan J, et al.
Cell
. 2008 Oct;
135(1):49-60.
PMID: 18854154
Human Immunodeficiency Viruses (HIV-1 and HIV-2) rely upon host-encoded proteins to facilitate their replication. Here, we combined genome-wide siRNA analyses with interrogation of human interactome databases to assemble a host-pathogen...
5.
Irelan J, Murphy T, DeJesus P, Teo H, Xu D, Gomez-Ferreria M, et al.
Proc Natl Acad Sci U S A
. 2007 Oct;
104(43):16940-5.
PMID: 17939994
IkappaB kinase 2 (IKK2 or IKKbeta) is a component of the IKK complex that coordinates the cellular response to a diverse set of extracellular stimuli, including cytokines, microbial infection, and...