Jeffrey Schmeckpeper
Overview
Explore the profile of Jeffrey Schmeckpeper including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
565
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Recent Articles
1.
Curry C, Sturgeon S, OGrady B, Yates A, Kjar A, Paige H, et al.
Biomaterials
. 2023 Nov;
303:122397.
PMID: 37979513
Critical limb ischemia (CLI) occurs when blood flow is restricted through the arteries, resulting in ulcers, necrosis, and chronic wounds in the downstream extremities. The development of collateral arterioles (i.e....
2.
Rodriguez Garcia M, Schmeckpeper J, Landim-Vieira M, Coscarella I, Fang X, Ma W, et al.
Int J Mol Sci
. 2023 Oct;
24(19).
PMID: 37834023
The gene encodes α-actinin 2, located in the Z-disc of the sarcomeres in striated muscle. In this study, we sought to investigate the effects of an missense variant of unknown...
3.
Curry C, Sturgeon S, OGrady B, Yates A, Kjar A, Paige H, et al.
bioRxiv
. 2023 Jun;
PMID: 37292898
Critical limb ischemia (CLI) occurs when blood flow is restricted through the arteries, resulting in ulcers, necrosis, and chronic wounds in the downstream extremities. The development of collateral arterioles (i.e....
4.
Schmeckpeper J, Kim K, George S, Blackwell D, Brennan J, Efimov I, et al.
J Mol Cell Cardiol
. 2023 Jun;
181:67-78.
PMID: 37285929
Diastolic Ca leak due to cardiac ryanodine receptor (RyR2) hyperactivity has been widely documented in chronic ischemic heart disease (CIHD) and may contribute to ventricular tachycardia (VT) risk and progressive...
5.
Blackwell D, Smith A, Do T, Gochman A, Schmeckpeper J, Hopkins C, et al.
J Pharmacol Exp Ther
. 2023 Mar;
385(3):205-213.
PMID: 36894328
The unnatural verticilide enantiomer (-verticilide) is a selective and potent inhibitor of cardiac ryanodine receptor (RyR2) calcium release channels and exhibits antiarrhythmic activity in a murine model of catecholaminergic polymorphic...
6.
Blackwell D, Schmeckpeper J, Knollmann B
Circ Res
. 2022 Jun;
130(12):1926-1964.
PMID: 35679367
Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide, accounting for 10% to 15% of all deaths. Although most arrhythmias are due to acquired heart disease, inherited channelopathies...
7.
Polcz M, Huston J, Breed M, Case M, Leisy P, Schmeckpeper J, et al.
Am Heart J Plus
. 2022 May;
15.
PMID: 35600671
Introduction: Clinical symptoms of heart failure commonly include fatigue, edema, and shortness of breath. Unfortunately, clinical monitoring has proven unreliable in predicting congestion and the need for hospitalization. Biosensing wearables...
8.
Egly C, Blackwell D, Schmeckpeper J, Delisle B, Weaver C, Knollmann B
Mol Pharmacol
. 2022 Feb;
101(4):236-245.
PMID: 35125346
Loss-of-function (LOF) variants in the K11.1 potassium channel cause long QT syndrome (LQTS). Most variants disrupt intracellular channel transport (trafficking) to the cell membrane. Since some channel inhibitors improve trafficking...
9.
Alvis B, Vaughn L, Schmeckpeper J, Huston J, Case M, Semler M, et al.
Crit Care Explor
. 2021 Oct;
3(10):e0539.
PMID: 34617035
Objectives: Due to the rapid rate of severe acute respiratory syndrome coronavirus 2 transmission and the heterogeneity of symptoms of coronavirus disease 2019, expeditious and effective triage is critical for...
10.
Wang L, Wada Y, Ballan N, Schmeckpeper J, Huang J, Rau C, et al.
J Mol Cell Cardiol
. 2021 Aug;
161:130-138.
PMID: 34400182
Background: Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have emerged as a promising tool for disease modeling and drug development. However, hiPSC-CMs remain functionally immature, which hinders their utility as a...