Jeffrey N Strathern
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Explore the profile of Jeffrey N Strathern including associated specialties, affiliations and a list of published articles.
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65
Citations
2913
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Recent Articles
1.
Flys T, Nissley D, Claasen C, Jones D, Shi C, Guay L, et al.
J Infect Dis
. 2019 Nov;
221(5):855.
PMID: 31776582
No abstract available.
2.
Bubunenko M, Court C, Rattray A, Gotte D, Kireeva M, Irizarry-Caro J, et al.
Genetics
. 2017 Mar;
206(1):179-187.
PMID: 28341651
We made a coupled genetic reporter that detects rare transcription misincorporation errors to measure RNA polymerase transcription fidelity in Using this reporter, we demonstrated that the transcript cleavage factor GreA,...
3.
Xu L, Wang W, Gotte D, Yang F, Hare A, Welch T, et al.
Proc Natl Acad Sci U S A
. 2016 Nov;
113(44):12426-12431.
PMID: 27791148
RNA polymerase II (pol II) encounters numerous barriers during transcription elongation, including DNA strand breaks, DNA lesions, and nucleosomes. Pyrrole-imidazole (Py-Im) polyamides bind to the minor groove of DNA with...
4.
Vermulst M, Denney A, Lang M, Hung C, Moore S, Moseley M, et al.
Nat Commun
. 2015 Oct;
6:8738.
PMID: 26465398
No abstract available.
5.
Vermulst M, Denney A, Lang M, Hung C, Moore S, Moseley M, et al.
Nat Commun
. 2015 Aug;
6:8065.
PMID: 26304740
Transcription errors occur in all living cells; however, it is unknown how these errors affect cellular health. To answer this question, we monitor yeast cells that are genetically engineered to...
6.
Rattray A, Santoyo G, Shafer B, Strathern J
PLoS Genet
. 2015 Jan;
11(1):e1004910.
PMID: 25569256
Mutations accumulate during all stages of growth, but only germ line mutations contribute to evolution. While meiosis contributes to evolution by reassortment of parental alleles, we show here that the...
7.
Irvin J, Kireeva M, Gotte D, Shafer B, Huang I, Kashlev M, et al.
PLoS Genet
. 2014 Sep;
10(9):e1004532.
PMID: 25232834
We developed a highly sensitive assay to detect transcription errors in vivo. The assay is based on suppression of a missense mutation in the active site tyrosine in the Cre...
8.
Imashimizu M, Kireeva M, Lubkowska L, Gotte D, Parks A, Strathern J, et al.
J Mol Biol
. 2012 Dec;
425(4):697-712.
PMID: 23238253
Pausing of RNA polymerase II (RNAP II) by backtracking on DNA is a major regulatory mechanism in control of eukaryotic transcription. Backtracking occurs by extrusion of the 3' end of...
9.
Amberg D, Burke D, Strathern J
CSH Protoc
. 2012 Apr;
2006(1).
PMID: 22485587
No abstract available.
10.
Amberg D, Burke D, Strathern J
CSH Protoc
. 2012 Apr;
2006(1).
PMID: 22485586
No abstract available.