Jeffrey M Purkerson
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Explore the profile of Jeffrey M Purkerson including associated specialties, affiliations and a list of published articles.
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19
Citations
227
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Recent Articles
1.
Borner K, Blood P, Silverstein J, Ruffalo M, Satija R, Teichmann S, et al.
Nat Methods
. 2025 Mar;
PMID: 40082611
The Human BioMolecular Atlas Program (HuBMAP) aims to construct a 3D Human Reference Atlas (HRA) of the healthy adult body. Experts from 20+ consortia collaborate to develop a Common Coordinate...
2.
Ushakumary M, Feng S, Bandyopadhyay G, Olson H, Weitz K, Huyck H, et al.
Am J Respir Cell Mol Biol
. 2024 Oct;
PMID: 39447176
The lung is a vital organ that undergoes extensive morphological and functional changes during postnatal development. To disambiguate how different cell populations contribute to organ development, we performed proteomic and...
3.
McLaughlin L, Zhang B, Sharma S, Knoten A, Kaushal M, Purkerson J, et al.
bioRxiv
. 2024 Aug;
PMID: 39211059
The human kidney is a vital organ with a remarkable ability to coordinate the activity of up to a million nephrons, its main functional tissue unit (FTU), and maintain homeostasis....
4.
Dylag A, Misra R, Bandyopadhyay G, Poole C, Huyck H, Jehrio M, et al.
Am J Physiol Lung Cell Mol Physiol
. 2023 Jul;
325(4):L419-L433.
PMID: 37489262
Bronchopulmonary dysplasia (BPD) is a disease of prematurity related to the arrest of normal lung development. The objective of this study was to better understand how proteome modulation and cell-type...
5.
Purkerson J, Everett C, Schwartz G
Physiol Rep
. 2022 Sep;
10(18):e15471.
PMID: 36151614
Acute pyelonephritis caused by uropathogenic E. coli (UPEC) can cause renal scarring and lead to development of chronic kidney disease. Prevention of kidney injury requires an understanding of host factors...
6.
Tsuruoka S, Purkerson J, Schwartz G
Sci Rep
. 2020 Nov;
10(1):20548.
PMID: 33239624
Acidosis is associated with E. coli induced pyelonephritis but whether bacterial cell wall constituents inhibit HCO transport in the outer medullary collecting duct from the inner stripe (OMCDi) is not...
7.
Purkerson J, Corley J, Schwartz G
Physiol Rep
. 2020 Oct;
8(19):e14525.
PMID: 33030238
Acute pyelonephritis is a common, serious bacterial infection in children. The prevalence of acute pyelonephritis is due at least in part to vesicoureteral reflux (VUR). Although an association between abnormalities...
8.
Peng H, Purkerson J, Freeman R, Schwaderer A, Schwartz G
Am J Physiol Renal Physiol
. 2019 Dec;
318(2):F468-F474.
PMID: 31841391
Acute pyelonephritis is frequently associated with metabolic acidosis. We previously reported that metabolic acidosis stimulates expression of hypoxia-inducible factor (HIF)-1α-induced target genes such as stromal derived factor-1 and cathelicidin, an...
9.
Peng H, Purkerson J, Schwaderer A, Schwartz G
Am J Physiol Renal Physiol
. 2017 Jul;
313(5):F1061-F1067.
PMID: 28747361
Intercalated cells of the collecting duct (CD) are critical for acid-base homeostasis and innate immune defense of the kidney. Little is known about the impact of acidosis on innate immune...
10.
Saxena V, Hains D, Ketz J, Chanley M, Spencer J, Becknell B, et al.
Am J Physiol Renal Physiol
. 2017 May;
315(4):F812-F823.
PMID: 28468965
The urinary tract is usually culture negative despite its close proximity to microbial flora. The precise mechanism by which the kidneys and urinary tract defends against infection is not well...