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Jeffrey C Lotz

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Articles 144
Citations 3563
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Recent Articles
1.
Wilson L, Beall D, Eastlack R, Berven S, Lotz J
Clinicoecon Outcomes Res . 2025 Jan; 17:19-31. PMID: 39872472
Background/context: Chronic low back pain (CLBP) is a significant US healthcare burden with millions of lumbar spine procedures annually. Diagnostic tests are essential to guide treatment but provocative discography (PD),...
2.
Hue T, Lotz J, Zheng P, Black D, Bailey J, Ewing S, et al.
medRxiv . 2024 Apr; PMID: 38645207
Objective: The University of California, San Francisco (UCSF) Core Center for Patient-centric, Mechanistic Phenotyping in Chronic Low Back Pain (REACH) is one of the three NIH Back Pain Consortium (BACPAC)...
3.
Gornet M, Peacock J, Ryken T, Schranck F, Eastlack R, Lotz J
Int J Spine Surg . 2024 Feb; PMID: 38413238
Purpose: Verifying lumbar disc pain can present a clinical challenge. Low-pressure provocative discography (PD) has served as the gold standard, although it is invasive and often a challenge to interpret....
4.
Lotz J, Ropella G, Anderson P, Yang Q, Hedderich M, Bailey J, et al.
JOR Spine . 2023 Dec; 6(4):e1300. PMID: 38156063
Chronic low back pain (LBP) is influenced by a broad spectrum of patient-specific factors as codified in domains of the biopsychosocial model (BSM). Operationalizing the BSM into research and clinical...
5.
Rosenberg J, Schaible E, Bostrom A, Lazar A, Graham J, Stanhope K, et al.
PNAS Nexus . 2023 Dec; 2(12):pgad363. PMID: 38094616
Understanding the biomechanical behavior of the intervertebral disc is crucial for studying disease mechanisms and developing tissue engineering strategies for managing disc degeneration. We used synchrotron small-angle X-ray scattering to...
6.
Gornet M, Eastlack R, Peacock J, Schranck F, Lotz J
Eur Spine J . 2023 Apr; 32(6):1973-1984. PMID: 37014434
Purpose: MRS was shown to reliably quantify relative levels of degenerative pain biomarkers, differentiating painful versus non-painful discs in patients with chronic discogenic low back pain (DLBP), and this correlates...
7.
Habib M, Hussien S, Jeon O, Lotz J, Wu P, Alsberg E, et al.
Front Bioeng Biotechnol . 2023 Mar; 11:1111356. PMID: 36923455
Poor nutrient transport through the cartilage endplate (CEP) is a key factor in the etiology of intervertebral disc degeneration and may hinder the efficacy of biologic strategies for disc regeneration....
8.
Halvorson R, Torres-Espin A, Callahan M, Tay B, ONeill C, Berven S, et al.
Eur Spine J . 2023 Mar; 32(4):1429-1436. PMID: 36877367
Purpose: The purpose of this study is to describe and assess the impact of multi-domain biopsychosocial (BPS) recovery on outcomes following lumbar spine fusion. We hypothesized that discrete patterns of...
9.
Bonnheim N, Lazar A, Kumar A, Akkaya Z, Zhou J, Guo X, et al.
Eur Spine J . 2023 Feb; 32(5):1517-1524. PMID: 36805320
Purpose: Clinical management of disc degeneration in patients with chronic low back pain (cLBP) is hampered by the challenge of distinguishing pathologic changes relating to pain from physiologic changes related...
10.
Ballatori A, Shahrestani S, Nyayapati P, Agarwal V, Krug R, Han M, et al.
JOR Spine . 2023 Jan; 5(4):e1217. PMID: 36601370
Introduction: Many studies have attempted to link multifidus (MF) fat infiltration with muscle quality and chronic low back pain (cLBP), but there is no consensus on these relationships. Methods: In...