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Jeffrey A Frelinger

Explore the profile of Jeffrey A Frelinger including associated specialties, affiliations and a list of published articles. Areas
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Articles 69
Citations 1915
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Recent Articles
1.
Vincent B, File D, McKinnon K, Moore D, Frelinger J, Collins E, et al.
J Immunol . 2023 May; 211(2):219-228. PMID: 37204246
Previous work from our group and others has shown that patients with breast cancer can generate a T cell response against specific human epidermal growth factor 2 (HER2) epitopes. In...
2.
Shubitz L, Powell D, Dial S, Butkiewicz C, Trinh H, Hsu A, et al.
J Fungi (Basel) . 2022 Oct; 8(10). PMID: 36294555
The majority of human coccidioidomycosis infections are asymptomatic or self-limited but may have sequestered spherules in highly structured granulomas. Under immunosuppression, reactivation of fungal growth can result in severe disease....
3.
Powell D, Shubitz L, Butkiewicz C, Trinh H, Donovan F, Frelinger J, et al.
Front Cell Infect Microbiol . 2022 Feb; 11:796114. PMID: 35174101
Tumor necrosis factor alpha (TNFα) is a pluripotent cytokine that is important in many infections, though its role in infection remains poorly understood. The need to understand TNFα in infection...
4.
Powell D, Hsu A, Shubitz L, Butkiewicz C, Moale H, Trinh H, et al.
Immunohorizons . 2022 Feb; 6(2):130-143. PMID: 35149520
STAT4 plays a critical role in the generation of both innate and adaptive immune responses. In the absence of STAT4, Th1 responses, critical for resistance to fungal disease, do not...
5.
Powell D, Hsu A, Butkiewicz C, Trinh H, Frelinger J, Holland S, et al.
Front Cell Infect Microbiol . 2022 Jan; 11:790488. PMID: 35071044
Disseminated coccidioidomycosis (DCM), often a severe and refractory disease leading to poor outcomes, is a risk for people with certain primary immunodeficiencies (PID). Several DCM-associated PID (STAT4, STAT3, IFNγ, and...
6.
Shubitz L, Robb E, Powell D, Bowen R, Bosco-Lauth A, Hartwig A, et al.
Vaccine . 2021 Oct; 39(47):6894-6901. PMID: 34696935
Coccidioidomycosis is a significant health problem of dogs and humans in endemic regions, especially California and Arizona in the U.S. Both species would greatly benefit from a vaccine to prevent...
7.
Wei W, Gibson H, Jacob J, Frelinger J, Berzofsky J, Maeng H, et al.
J Immunol . 2020 Aug; 205(6):1554-1563. PMID: 32796024
The genetic basis and mechanisms of disparate antitumor immune response was investigated in Diversity Outbred (DO) F1 mice that express human HER2. DO mouse stock samples nearly the entire genetic...
8.
Shubitz L, Powell D, Butkiewicz C, Lewis M, Trinh H, Frelinger J, et al.
J Infect Dis . 2020 Jul; 223(1):166-173. PMID: 32658292
Murine infections with most Coccidioides spp. strains are lethal by 3 weeks, limiting the study of immune responses. Coccidioides posadasii, strain 1038 (Cp1038), while slowly lethal, resulted in protracted survival...
9.
Powell D, Ma M, So M, Frelinger J
Immunohorizons . 2019 Apr; 2(9):305-313. PMID: 31022695
, isolated from the oral cavity of wild-caught mice, does not colonize most inbred mouse strains. does weakly (50%) colonize C57BL/6J (B6) mice but readily colonizes CAST/EiJ (CAST) mice. In...
10.
Smithey M, Venturi V, Davenport M, Buntzman A, Vincent B, Frelinger J, et al.
Proc Natl Acad Sci U S A . 2018 Jul; 115(29):E6817-E6825. PMID: 29967140
Lifelong interactions between host and the ubiquitous and persistent cytomegalovirus (CMV) have been proposed to contribute to the age-related decline in immunity. Prior work from us and others found some...