Jeffrey A Farrell
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Explore the profile of Jeffrey A Farrell including associated specialties, affiliations and a list of published articles.
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20
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3671
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Recent Articles
1.
Wang Y, Liu J, Du L, Wyss J, Farrell J, Schier A
Dev Cell
. 2024 Nov;
60(4):581-598.e9.
PMID: 39591963
During differentiation, cells become structurally and functionally specialized, but comprehensive views of the underlying remodeling processes are elusive. Here, we leverage single-cell RNA sequencing (scRNA-seq) developmental trajectories to reconstruct differentiation...
2.
Sposato A, Hollins H, Llewellyn D, Weber J, Schrock M, Farrell J, et al.
Development
. 2024 Oct;
151(22).
PMID: 39470160
Vertebrate spermatogonial stem cells maintain sperm production over the lifetime of an animal, but fertility declines with age. Although morphological studies have informed our understanding of typical spermatogenesis, the molecular...
3.
Fishman L, Modak A, Nechooshtan G, Razin T, Erhard F, Regev A, et al.
Nat Commun
. 2024 Apr;
15(1):3104.
PMID: 38600066
During embryonic development, pluripotent cells assume specialized identities by adopting particular gene expression profiles. However, systematically dissecting the relative contributions of mRNA transcription and degradation to shaping those profiles remains...
4.
Wang Y, Liu J, Du L, Wyss J, Farrell J, Schier A
bioRxiv
. 2024 Jan;
PMID: 38234833
During differentiation, cells become structurally and functionally specialized, but comprehensive views of the underlying remodeling processes are elusive. Here, we leverage scRNA-seq developmental trajectories to reconstruct differentiation using two secretory...
5.
Single-cell analysis of shared signatures and transcriptional diversity during zebrafish development
Sur A, Wang Y, Capar P, Margolin G, Prochaska M, Farrell J
Dev Cell
. 2023 Nov;
58(24):3028-3047.e12.
PMID: 37995681
During development, animals generate distinct cell populations with specific identities, functions, and morphologies. We mapped transcriptionally distinct populations across 489,686 cells from 62 stages during wild-type zebrafish embryogenesis and early...
6.
Sposato A, Llewellyn D, Weber J, Hollins H, Schrock M, Farrell J, et al.
bioRxiv
. 2023 Sep;
PMID: 37732254
Vertebrate spermatogonial stem cells maintain sperm production over the lifetime of an animal but fertility declines with age. While morphological studies have greatly informed our understanding of typical spermatogenesis, the...
7.
Fishman L, Nechooshtan G, Erhard F, Regev A, Farrell J, Rabani M
bioRxiv
. 2023 May;
PMID: 37131717
During embryonic development, pluripotent cells assume specialized identities by adopting particular gene expression profiles. However, systematically dissecting the underlying regulation of mRNA transcription and degradation remains a challenge, especially within...
8.
Primack A, Cazet J, Little H, Muhlbauer S, Cox B, David C, et al.
bioRxiv
. 2023 Mar;
PMID: 36993575
The small freshwater cnidarian polyp uses adult stem cells (interstitial stem cells) to continually replace neurons throughout its life. This feature, combined with the ability to image the entire nervous...
9.
Single-cell analysis of shared signatures and transcriptional diversity during zebrafish development
Sur A, Wang Y, Capar P, Margolin G, Farrell J
bioRxiv
. 2023 Mar;
PMID: 36993555
During development, animals generate distinct cell populations with specific identities, functions, and morphologies. We mapped transcriptionally distinct populations across 489,686 cells from 62 stages during wild-type zebrafish embryogenesis and early...
10.